对Heiligenberger、C57BI以及Heiligenberger与C57BI杂交的小鼠品系中辐射诱导畸形频率敏感性差异的遗传学特征分析。

A genetic characterization of differences in the sensitivity to radiation-induced malformation frequencies in the mouse strains Heiligenberger, C57BI, and Heiligenberger x C57BI.

作者信息

Muller W U, Streffer C, Knoelker M

机构信息

Institut fur Medizinische Strahlenbiologie, Universitatsklinikum Essen, Germany.

出版信息

Radiat Environ Biophys. 1996 Feb;35(1):37-40. doi: 10.1007/BF01211241.

DOI:10.1007/BF01211241

PMID:8907643

Abstract

We studied the frequency of malformations induced in two mouse strains (Heiligenberger, C57B1/6J) by exposure to x-rays 3 h after conception. Whereas there was a high number of malformed fetuses in Heiligenberger mice (mostly gastroschises) on day 19 of pregnancy, C57B1 did not respond to radiation exposure shortly after conception with an increased frequency of malformed fetuses. Cross-breeding of both strains revealed that no statistically significant increase in radiation-induced malformations was obtained in the F1 fetuses when the father was Heiligenberger and the mother C57B1. In the opposite case (Heiligenberger mother, C57B1 father) a small but statistically significant increase was observed.

摘要

我们研究了受孕后3小时暴露于X射线下的两种小鼠品系（海利根贝格小鼠、C57B1/6J小鼠）中畸形的发生频率。在妊娠第19天，海利根贝格小鼠中有大量畸形胎儿（大多为腹裂），而C57B1小鼠在受孕后不久接受辐射暴露时，畸形胎儿的频率并未增加。两种品系的杂交显示，当父亲是海利根贝格小鼠而母亲是C57B1小鼠时，F1代胎儿中辐射诱导的畸形没有统计学上的显著增加。在相反的情况（海利根贝格小鼠母亲，C57B1小鼠父亲）下，观察到有小幅但具有统计学意义的增加。