小鼠7号染色体上辐射诱导腹裂的一个基因座。
A locus for radiation-induced gastroschisis on mouse Chromosome 7.
作者信息
Hillebrandt S, Streffer C, Montagutelli X, Balling R
机构信息
Institut für Medizinische Strahlenbiologie, Universitätsklinikum Essen, Hufelandstr.55, 45122 Essen, Germany.
出版信息
Mamm Genome. 1998 Dec;9(12):995-7. doi: 10.1007/s003359900913.
Gastroschisis (abdominal wall defects) occurs with a high frequency in the mouse inbred strain HLG compared with C57BL/6J mice. The risk of gastroschisis increases significantly after exposure to irradiation with X-rays during preimplantation development and follows a recessive mode of inheritance for the HLG susceptibility alleles. We have used a backcross strategy and genome-wide microsatellite typing to chromosomally map this trait. A suggestive linkage for a locus responsible for radiation-induced gastroschisis (Rigs1) was found in a region of mouse Chromosome 7.
与C57BL/6J小鼠相比，腹裂（腹壁缺损）在近交系小鼠HLG中具有较高的发生率。在植入前发育期间暴露于X射线辐射后，腹裂的风险显著增加，并且HLG易感性等位基因遵循隐性遗传模式。我们采用了回交策略和全基因组微卫星分型来对这一性状进行染色体定位。在小鼠7号染色体的一个区域发现了一个与辐射诱导的腹裂（Rigs1）相关位点的暗示性连锁。
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