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热疗和百草枯诱导的酿酒酵母G1期阻滞与RAD9基因无关。

Hyperthermia and paraquat-induced G1 arrest in the yeast Saccharomyces cerevisiae is independent of the RAD9 gene.

作者信息

Nunes E, Siede W

机构信息

Departemento de Biofisica, Facultad de Medicina, Montevideo, Uruguay.

出版信息

Radiat Environ Biophys. 1996 Feb;35(1):55-7. doi: 10.1007/BF01211243.

DOI:10.1007/BF01211243
PMID:8907645
Abstract

Mutants of the RAD9 gene of Saccharomyces cerevisiae are defective in cell cycle checkpoint arrest in G1 and G2 after treatment with DNA-damaging agents. It is demonstrated that the pronounced G1 arrest observed in yeast after hyperthermia treatment or exposure to paraquat-generated superoxide radicals does not depend on a functional RAD9 gene. For both types of treatments, the mechanism of cell cycle arrest must be considered different from the activation of the DNA damage checkpoint response.

摘要

酿酒酵母RAD9基因的突变体在经DNA损伤剂处理后，在G1期和G2期的细胞周期检查点停滞方面存在缺陷。结果表明，酵母在热疗或暴露于百草枯产生的超氧自由基后观察到的明显的G1期停滞并不依赖于功能性RAD9基因。对于这两种处理类型，细胞周期停滞的机制必须被认为不同于DNA损伤检查点反应的激活。

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本文引用的文献

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Control of the yeast cell cycle by the Cdc28 protein kinase.Cdc28蛋白激酶对酵母细胞周期的调控。
Curr Opin Cell Biol. 1993 Apr;5(2):166-79. doi: 10.1016/0955-0674(93)90099-c.
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Heat shock-mediated cell cycle blockage and G1 cyclin expression in the yeast Saccharomyces cerevisiae.热休克介导的酿酒酵母细胞周期阻滞及G1期细胞周期蛋白表达
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Cell-cycle arrest and inhibition of G1 cyclin translation by iron in AFT1-1(up) yeast.铁在AFT1-1（上调）酵母中导致细胞周期停滞并抑制G1期细胞周期蛋白的翻译。
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Proc Natl Acad Sci U S A. 1993 Sep 1;90(17):7985-9. doi: 10.1073/pnas.90.17.7985.
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Cell. 1993 Nov 19;75(4):729-39. doi: 10.1016/0092-8674(93)90493-a.
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Apoptosis in cancer therapy: crossing the threshold.癌症治疗中的细胞凋亡：跨越阈值
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Cell cycle control and cancer.细胞周期调控与癌症。
Science. 1994 Dec 16;266(5192):1821-8. doi: 10.1126/science.7997877.
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Genetics. 1994 Oct;138(2):271-81. doi: 10.1093/genetics/138.2.271.
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DNA polymerase epsilon links the DNA replication machinery to the S phase checkpoint.DNA聚合酶ε将DNA复制机制与S期检查点联系起来。
Cell. 1995 Jan 13;80(1):29-39. doi: 10.1016/0092-8674(95)90448-4.