Laboratory of Structural and Functional Organization of Chromosomes, Institute of Gene Biology, Russian Academy of Sciences, 119334, Moscow, Russia.
Cell Mol Life Sci. 2013 Nov;70(22):4229-41. doi: 10.1007/s00018-013-1348-7. Epub 2013 Apr 30.
Heat shock (HS) is one of the best-studied exogenous cellular stresses. The cellular response to HS utilizes ancient molecular networks that are based primarily on the action of stress-induced heat shock proteins and HS factors. However, in one way or another, all cellular compartments and metabolic processes are involved in such a response. In this review, we aimed to summarize the experimental data concerning all aspects of the HS response in mammalian cells, such as HS-induced structural and functional alterations of cell membranes, the cytoskeleton and cellular organelles; the associated pathways that result in different modes of cell death and cell cycle arrest; and the effects of HS on transcription, splicing, translation, DNA repair, and replication.
热休克 (HS) 是研究最为广泛的外源性细胞应激之一。细胞对热休克的反应利用了古老的分子网络，主要基于应激诱导的热休克蛋白和 HS 因子的作用。然而，无论以何种方式，所有的细胞区室和代谢过程都参与了这种反应。在这篇综述中，我们旨在总结有关哺乳动物细胞热休克反应各个方面的实验数据，如热休克诱导的细胞膜、细胞骨架和细胞器的结构和功能改变；导致不同细胞死亡和细胞周期阻滞模式的相关途径；以及热休克对转录、剪接、翻译、DNA 修复和复制的影响。
