McClellan D R, Francis G L
Division of Pediatric Endocrinology, Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA.
Endocrinol Metab Clin North Am. 1996 Mar;25(1):27-48. doi: 10.1016/s0889-8529(05)70311-x.
Differentiated thyroid cancer may have a different clinical course when it develops in children, pregnant women, and patients with Graves' disease. Thyroid nodules which develop in these patients appear to have a greater risk of malignancy and should be evaluated aggressively. Treatment in all cases includes operation followed by radioactive iodine ablation (in the nonpregnant patient) and thyroid hormone suppression. Follow-up, including serum Tg and yearly thyroid scans, should be continued as long as possible.