Suzuki M, Nagata S, Hiramatsu K, Takagi I, Ito H, Kitao S, Ito M, Ohta N, Baba S
Department of Otorhinolaryngology, Nagoya City University Medical School, Japan.
Acta Otolaryngol Suppl. 1996;525:108-12.
To clarify how Epstein-Barr virus (EBV) infection is responsible for Sjögren's syndrome (SjS) we measured both IgG and IgM antibodies to viral capsid antigen (VCA) of EBV in the sera of normal healthy subjects and patients with SjS. Anti-VCA IgG was detectable in all controls and patients however, anti-VCA IgG titers in the sera of SjS patients were significantly higher than those of the controls (p < 0.01). No anti-VCA IgM was detected in the sera of controls whereas anti-VCA IgM was detected in the sera from 10 out of the 13 patients with SjS. This suggests that SjS might be associated with EBV. The serum levels of sCD23 (IgE-binding factor) were also measured to assess the differential state in patients with SjS. The sCD23 level of normal individuals was 211.26 +/- 12.01 micrograms/L (value is mean +/- SE), and was 443.77 +/- 71.94 micrograms/L in the 13 patients with SjS. The mean sCD23 level in the 9 patients with SjS without any complication was 360.67 +/- 35.63 micrograms/L. In the patients with SjS, sCD23 levels were significantly higher than those in the normal individuals (p < 0.01).
为了阐明爱泼斯坦-巴尔病毒（EBV）感染如何导致干燥综合征（SjS），我们检测了正常健康受试者和SjS患者血清中针对EBV病毒衣壳抗原（VCA）的IgG和IgM抗体。在所有对照和患者中均检测到抗VCA IgG，然而，SjS患者血清中的抗VCA IgG滴度显著高于对照组（p < 0.01）。在对照组血清中未检测到抗VCA IgM，而在13例SjS患者中的10例血清中检测到抗VCA IgM。这表明SjS可能与EBV有关。还检测了sCD23（IgE结合因子）的血清水平，以评估SjS患者的差异状态。正常个体的sCD23水平为211.26 +/- 12.01微克/升（值为平均值 +/- 标准误），13例SjS患者的sCD23水平为443.77 +/- 71.94微克/升。9例无任何并发症的SjS患者的平均sCD23水平为360.67 +/- 35.63微克/升。在SjS患者中，sCD23水平显著高于正常个体（p < 0.01）。
