Bakke A, Myhr K M, Grønning M, Nyland H
Department of Surgery, Haukeland Hospital, Bergen, Norway.
Scand J Urol Nephrol Suppl. 1996;179:61-6.
A population-based cohort study focusing on bladder, bowel and sexual dysfunction in MS-patients was performed. The total cohort under study comprised 209 patients. The duration of the disease was nine to 19 years. A total of 57.5% reported some to major bladder dysfunction. The corresponding figures of bowel and sexual dysfunction were 41.3% and 51% respectively. The dysfunction increased with higher age, higher age at onset of MS, duration and course of the disease. The most unfavourable course of the disease was the relapsing remittent secondary progressive form, where almost 70% became worse during an eight year's observation period, in contrast to patients with the relapsing remittent form, where less than 30% became worse. The study shows that a high number of MS patients is in need of a neuro-urological work-up, and that effort should be made to prevent or delay a secondary progressive course of the disease.
开展了一项基于人群的队列研究，聚焦于多发性硬化症（MS）患者的膀胱、肠道及性功能障碍。所研究的总队列包括209名患者。病程为9至19年。共有57.5%的患者报告有轻度至重度膀胱功能障碍。肠道和性功能障碍的相应比例分别为41.3%和51%。功能障碍随着年龄增长、MS发病年龄增大、疾病持续时间及病程而增加。最不利的病程是复发缓解继发进展型，在八年观察期内近70%的患者病情恶化，相比之下，复发缓解型患者病情恶化的比例不到30%。该研究表明，大量MS患者需要进行神经泌尿学检查，并且应努力预防或延缓疾病的继发进展病程。
