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Immunosuppression in human tumor-host interaction: role of cytokines and alterations in signal-transducing molecules.

作者信息

Kiessling R, Kono K, Petersson M, Wasserman K

机构信息

Microbiology and Tumor Biology Center (MTC), Karolinska Institute, Stockholm, Sweden.

出版信息

Springer Semin Immunopathol. 1996;18(2):227-42. doi: 10.1007/BF00820668.

DOI:10.1007/BF00820668
PMID:8908702
Abstract
摘要

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Immunosuppression in human tumor-host interaction: role of cytokines and alterations in signal-transducing molecules.人类肿瘤-宿主相互作用中的免疫抑制：细胞因子的作用及信号转导分子的改变
Springer Semin Immunopathol. 1996;18(2):227-42. doi: 10.1007/BF00820668.
2
Alterations in signal transducing molecule CD3 zeta in patients with neoplastic diseases.肿瘤疾病患者信号转导分子CD3ζ的改变。
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[Tumor microenvironment: regulatory cells and immunosuppressive cytokines].[肿瘤微环境：调节性细胞与免疫抑制细胞因子]
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6
Mechanisms by which cytokines signal the brain.细胞因子向大脑发出信号的机制。
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Anti-tumor immunity and mechanism of immunosuppression mediated by tumor cells: role of tumor-derived soluble factors and cytokines.肿瘤细胞介导的抗肿瘤免疫与免疫抑制机制：肿瘤来源的可溶性因子和细胞因子的作用。
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Mechanisms of soluble mediators.可溶性介质的作用机制。
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Gene Expression Profile of T-cell Receptors in the Synovium, Peripheral Blood, and Thymus during the Initial Phase of Collagen-induced Arthritis.胶原诱导性关节炎初始阶段滑膜、外周血和胸腺中 T 细胞受体的基因表达谱。
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Increase in tumour-infiltrating lymphocytes with regulatory T cell immunophenotypes and reduced zeta-chain expression in nasopharyngeal carcinoma patients.

本文引用的文献

1
Alterations in expression and function of signal-transducing proteins in tumor-associated T and natural killer cells in patients with ovarian carcinoma.卵巢癌患者肿瘤相关T细胞和自然杀伤细胞中信号转导蛋白的表达及功能改变。
Clin Cancer Res. 1996 Jan;2(1):161-73.
2
Alterations in T cell receptor and signal transduction molecules in melanoma patients.黑色素瘤患者T细胞受体及信号转导分子的改变
Clin Cancer Res. 1995 Nov;1(11):1327-35.
3
Alterations in T cells of cancer-bearers: whence specificity?癌症患者T细胞的改变：特异性从何而来？
鼻咽癌患者中具有调节性T细胞免疫表型的肿瘤浸润淋巴细胞增加及ζ链表达降低。
Clin Exp Immunol. 2009 Mar;155(3):412-22. doi: 10.1111/j.1365-2249.2008.03793.x.
4
The tumor microenvironment and its role in promoting tumor growth.肿瘤微环境及其在促进肿瘤生长中的作用。
Oncogene. 2008 Oct 6;27(45):5904-12. doi: 10.1038/onc.2008.271.
5
SPARC ameliorates ovarian cancer-associated inflammation.富含半胱氨酸的酸性分泌蛋白可改善卵巢癌相关炎症。
Neoplasia. 2008 Oct;10(10):1092-104. doi: 10.1593/neo.08672.
6
Antioxidant agents are effective in inducing lymphocyte progression through cell cycle in advanced cancer patients: assessment of the most important laboratory indexes of cachexia and oxidative stress.抗氧化剂对晚期癌症患者淋巴细胞通过细胞周期的进程具有诱导作用：恶病质和氧化应激最重要实验室指标的评估
J Mol Med (Berl). 2003 Oct;81(10):664-73. doi: 10.1007/s00109-003-0476-1. Epub 2003 Aug 19.
7
Alleviating oxidative stress in cancer immunotherapy: a role for histamine?减轻癌症免疫治疗中的氧化应激：组胺的作用？
Med Oncol. 2000 Nov;17(4):258-69. doi: 10.1007/BF02782190.
8
Down-regulation of the T cell receptor CD3 zeta chain in rheumatoid arthritis (RA) and its influence on T cell responsiveness.类风湿关节炎（RA）中T细胞受体CD3 ζ链的下调及其对T细胞反应性的影响。
Clin Exp Immunol. 2000 Apr;120(1):174-82. doi: 10.1046/j.1365-2249.2000.01180.x.
9
T-cell dysfunction in a patient with short bowel syndrome: report of a case.短肠综合征患者的T细胞功能障碍：病例报告
Surg Today. 1999;29(12):1253-6. doi: 10.1007/BF02482217.
Immunol Today. 1996 Aug;17(8):365-8. doi: 10.1016/0167-5699(96)10013-X.
4
Hydrogen peroxide secreted by tumor-derived macrophages down-modulates signal-transducing zeta molecules and inhibits tumor-specific T cell-and natural killer cell-mediated cytotoxicity.肿瘤来源的巨噬细胞分泌的过氧化氢可下调信号转导ζ分子，并抑制肿瘤特异性T细胞和自然杀伤细胞介导的细胞毒性。
Eur J Immunol. 1996 Jun;26(6):1308-13. doi: 10.1002/eji.1830260620.
5
Impaired cytokine production in whole blood cell cultures of patients with urological carcinomas.泌尿系统癌症患者全血细胞培养中细胞因子产生受损。
J Cancer Res Clin Oncol. 1993;119(7):430-3. doi: 10.1007/BF01218426.
6
T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors.浸润肾细胞癌的T细胞即使能够产生白细胞介素2并表达白细胞介素2受体，但其增殖反应仍较差。
Cancer Res. 1993 Mar 15;53(6):1380-7.
7
Cell surface control of the multiubiquitination and deubiquitination of high-affinity immunoglobulin E receptors.高亲和力免疫球蛋白E受体多聚泛素化和去泛素化的细胞表面调控
EMBO J. 1993 Feb;12(2):779-86. doi: 10.1002/j.1460-2075.1993.tb05712.x.
8
Cytokine regulation of tumour-associated macrophages.细胞因子对肿瘤相关巨噬细胞的调控
Res Immunol. 1993 May;144(4):280-3; discussion 294-8. doi: 10.1016/0923-2494(93)80108-b.
9
Interleukin 10 transfected into Chinese hamster ovary cells prevents tumor growth and macrophage infiltration.转染到中国仓鼠卵巢细胞中的白细胞介素10可抑制肿瘤生长并阻止巨噬细胞浸润。
Cancer Res. 1993 Sep 15;53(18):4134-7.
10
Interferon-gamma reduces tumor-induced Ia- macrophage-mediated suppression: role of prostaglandin E2, Ia, and tumor necrosis factor-alpha.γ干扰素可减轻肿瘤诱导的Ia巨噬细胞介导的抑制作用：前列腺素E2、Ia和肿瘤坏死因子α的作用。
Immunopharmacology. 1993 May-Jun;25(3):215-27. doi: 10.1016/0162-3109(93)90050-z.