白色念珠菌菌株在CFW1小鼠和Sprague-Dawley大鼠中的相对毒力。

Comparative virulence of Candida albicans strains in CFW1 mice and Sprague-Dawley rats.

作者信息

Schmidt A, Geschke U

机构信息

Institute for Chemotherapy, Pharma Research, Bayer AG, Wuppertal, FR Germany.

出版信息

Mycoses. 1996 May-Jun;39(5-6):157-60. doi: 10.1111/j.1439-0507.1996.tb00119.x.

DOI:10.1111/j.1439-0507.1996.tb00119.x

PMID:8909024

Abstract

To verify host-species specificities of virulence of Candida albicans in experimental systemic mycoses, 10 ATCC strains of Candida albicans, were compared for their virulence in CFW1 mice and Sprague-Dawley rats. Virulence was parallel in mice and rats, four strains were avirulent (ATCC 10231, 18804, 38245, 44831), one strain had an intermediate virulence (ATCC 32354), and five strains (ATCC 10261, 44373, 44505, 62342, 90028) were highly virulent in both host species. Infection doses of 2 x 10(6) CFU per mouse and 5 x 10(6) CFU per rat were comparable with respect to mortality of animals within 10 days; this represents a 4 : 1 ratio on the basis of body weight. In Sprague-Dawley rats haemorrhage occurred in infections with all virulent strains which was not observed in CFW1 mice.

摘要

为验证白色念珠菌在实验性系统性真菌病中毒力的宿主物种特异性，比较了10株美国典型培养物保藏中心（ATCC）的白色念珠菌菌株在CFW1小鼠和斯普拉格-道利大鼠中的毒力。小鼠和大鼠中的毒力情况相似，4株菌株无毒力（ATCC 10231、18804、38245、44831），1株菌株具有中等毒力（ATCC 32354），5株菌株（ATCC 10261、44373、44505、62342、90028）在两种宿主物种中均具有高毒力。每只小鼠2×10⁶CFU和每只大鼠5×10⁶CFU的感染剂量在10天内动物死亡率方面具有可比性；基于体重，这代表了4:1的比例。在斯普拉格-道利大鼠中，所有有毒力的菌株感染时均出现出血，而在CFW1小鼠中未观察到这种情况。