Shimizu M T, Almeida N Q, Fantinato V, Unterkircher C S
Department of Pathology, School of Dentistry, Universidade Estadual Paulista Julio de Mesquita Filho UNESP, Säo José dos Campos, SP, Brazil.
Mycoses. 1996 May-Jun;39(5-6):161-7. doi: 10.1111/j.1439-0507.1996.tb00120.x.
We studied the ability of different Candida species to produce, at the same time, hyaluronidase, chondroitin sulphatase, proteinase, and phospholipase to assess whether they could be related to Candida pathogenicity. Only C. albicans was able to produce the four enzymes tested (73%) and was highly virulent to mice. Strains, that lack the capacity to produce one or more of the enzymes assayed, seemed less virulent or avirulent, similarly to the spontaneous hyaluronidase, chondroitin sulphatase, phospholipase and proteinase-deficient C. albicans strain FCF 14, 1 which was non-pathogenic to mice. Among the other Candida species tested, none of them produced the four enzymes simultaneously, being less virulent in intravenously inoculated mice.
我们研究了不同念珠菌属物种同时产生透明质酸酶、硫酸软骨素酶、蛋白酶和磷脂酶的能力，以评估它们是否与念珠菌的致病性有关。只有白色念珠菌能够产生所测试的四种酶（73%），并且对小鼠具有高度毒性。缺乏产生一种或多种所检测酶能力的菌株，似乎毒性较低或无毒性，这与自发缺乏透明质酸酶、硫酸软骨素酶、磷脂酶和蛋白酶的白色念珠菌菌株FCF 14,1相似，该菌株对小鼠无致病性。在测试的其他念珠菌属物种中，没有一种能同时产生这四种酶，在静脉接种小鼠时毒性较低。
