Pec J, Palencarova E, Plank L, Straka S, Pec M, Jesenska Z, Filo V
Department of Dermatology, University Hospital, Slovak Republic.
Mycoses. 1996 May-Jun;39(5-6):217-21. doi: 10.1111/j.1439-0507.1996.tb00128.x.
A case of phaeohyphomycosis caused by strains of both Alternaria spp. and Phaeosclera dematioides is presented. The biopsy material was studied using histological, immunohistochemical and transmission electron microscopy techniques. The agent's dematiaceous mycelia are composed of thick-walled hyphae, branched and unbranched, with terminal vesicular formations. All the described structures occur alone or in chains within multinuclear giant foreign body-type cells or invading an abscess. Also present are budding forms. Immunostaining of histiocytic inflammatory cells in either. diffuse or granulomatous infiltrates revealed cytoplasmic positivity for lysozyme and Ki-MIP antibody. The lymphocytic infiltrates of the upper corium show predominantly small T lymphocytes (CD3 and CD45RO positive) and absence of CD20-positive B cells. Plasma cells occurring within the infiltrates of the deeper parts show polyclonal expression of both Ig light chains.
本文报告1例由链格孢属菌株和皮炎暗色丝孢霉引起的暗色丝孢霉病。使用组织学、免疫组织化学和透射电子显微镜技术对活检材料进行了研究。病原体的暗色菌丝体由厚壁菌丝组成，有分支和无分支，有末端囊泡形成。所有所述结构单独或成链状存在于多核巨异物型细胞内或侵入脓肿。也有芽生形式。在弥漫性或肉芽肿性浸润中的组织细胞炎性细胞免疫染色显示溶菌酶和Ki-MIP抗体的细胞质阳性。真皮上层的淋巴细胞浸润主要显示小T淋巴细胞（CD3和CD45RO阳性），且无CD20阳性B细胞。深部浸润内出现的浆细胞显示两种Ig轻链的多克隆表达。
