一名儿童使用缓释更昔洛韦植入物治疗双侧巨细胞病毒性视网膜炎。
Treatment of bilateral cytomegalovirus retinitis with sustained-release ganciclovir implants in a child.
作者信息
Malley D S, Barone R, Heinemann M H
机构信息
Department of Ophthalmology, New York Hospital-Cornell Medical Center, New York, USA.
出版信息
Am J Ophthalmol. 1996 Nov;122(5):731-2. doi: 10.1016/s0002-9394(14)70496-9.
PURPOSE
To report treatment of bilateral cytomegalovirus (CMV) retinitis in an 11-year-old girl with acquired immunodeficiency syndrome (AIDS).
METHOD
Case report describing the use of intravitreal ganciclovir sustained-release devices to treat CMV retinitis, involving zones 1 through 3, which progressed despite single and combination intravenous therapy with ganciclovir and foscarnet.
RESULTS
Stabilization with no active CMV retinitis was achieved after bilateral implantation of intravitreal sustained-release ganciclovir devices. There was no reactivation of the retinitis during the 5 months of follow-up.
CONCLUSION
Sustained-release ganciclovir implants can be used to achieve local control of CMV retinitis in the pediatric patient.
目的
报告一名11岁获得性免疫缺陷综合征（AIDS）女孩双侧巨细胞病毒（CMV）视网膜炎的治疗情况。
方法
病例报告，描述使用玻璃体内更昔洛韦缓释装置治疗CMV视网膜炎，病变累及1至3区，尽管采用更昔洛韦和膦甲酸钠单一及联合静脉治疗，病情仍进展。
结果
双侧植入玻璃体内更昔洛韦缓释装置后，CMV视网膜炎无活动，病情稳定。随访5个月期间视网膜炎未复发。
结论
更昔洛韦缓释植入物可用于实现对儿童患者CMV视网膜炎的局部控制。
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