Sasseville V G, Smith M M, Mackay C R, Pauley D R, Mansfield K G, Ringler D J, Lackner A A
Division of Comparative Pathology, New England Regional Primate Research Center, Southborough, Massachusetts 01772-9102, USA.
Am J Pathol. 1996 Nov;149(5):1459-67.
The pathogenesis of neurological dysfunction associated with human immunodeficiency (HIV)-1 infection is uncertain. However, the presence of macrophage infiltrates in the central nervous system is a key feature of HIV encephalitis and is correlated with HIV-associated dementia. Moreover, it has been demonstrated that HIV-infected monocyte/macrophages can produce toxic substances that may play a critical role in the development of HIV-associated dementia. However, the exact mechanisms responsible for HIV infection and leukocyte recruitment to the central nervous system remain speculative. Similar to HIV-infected patients, simian immunodeficiency virus (SIV)-infected macaque monkeys develop immunosuppression and acquired immune deficiency syndrome (AIDS)-related inflammatory disorders, including AIDS encephalitis. In this study, we demonstrate that encephalitic brain from SIV-infected animals has elevated immunohistochemical expression of the C-C chemokines, macrophage inflammatory protein-1 alpha and -beta, RANTES, and monocyte chemotactic protein-3, and the C-X-C chemokine interferon-inducible protein-10. These findings suggest that one or all of of these chemokines could be involved in leukocyte recruitment to the brain in SIV-infected macaque monkeys.
与人类免疫缺陷病毒（HIV）-1感染相关的神经功能障碍的发病机制尚不清楚。然而，中枢神经系统中巨噬细胞浸润的存在是HIV脑炎的一个关键特征，并且与HIV相关痴呆相关。此外，已经证明，被HIV感染的单核细胞/巨噬细胞可产生可能在HIV相关痴呆的发展中起关键作用的有毒物质。然而，导致HIV感染以及白细胞募集至中枢神经系统的确切机制仍具有推测性。与HIV感染患者相似，感染猿猴免疫缺陷病毒（SIV）的猕猴会出现免疫抑制和获得性免疫缺陷综合征（AIDS）相关的炎症性疾病，包括AIDS脑炎。在本研究中，我们证明，来自感染SIV动物的脑炎脑内，C-C趋化因子、巨噬细胞炎性蛋白-1α和-β、调节激活正常T细胞表达和分泌因子（RANTES）以及单核细胞趋化蛋白-3，以及C-X-C趋化因子干扰素诱导蛋白-10的免疫组化表达升高。这些发现表明，这些趋化因子中的一种或全部可能参与了感染SIV的猕猴中白细胞向脑内的募集。
