Sharpe T J, Smith H
Int Arch Allergy Appl Immunol. 1979;60(2):216-21. doi: 10.1159/000232344.
When actively sensitised rats were injected intraperitoneally with antigen, the local reaction that ensued can be divided into two phases: an immediate reaction characterised by histamine and SRS-A release with an associated extravasation of plasma proteins, and a later reaction involving infiltration of neutrophilic polymorphonuclear leucocytes. When the immediate reaction was modified by BRL 10833 (which inhibits histamine release from rat mast cells and reduces extravasation of plasma proteins), there was no reduction in neutrophil infiltration. FPL 55712, an SRS-A antagonist, also failed to inhibit neutrophil infiltration. The beta-adrenoreceptor stimulants isoprenaline and salbutamol reduced neutrophil infiltration. Isoprenaline inhibited the extravasation of plasma proteins when given before antigen, but even when administered to rats after antigen, when extravasation was complete, it still inhibited neutrophil infiltration. Propranolol reversed isoprenaline-induced inhibition of neutrophil infiltration.
当向主动致敏的大鼠腹腔内注射抗原时，随之发生的局部反应可分为两个阶段：一个是即刻反应，其特征为组胺和慢反应物质A（SRS-A）释放，伴有血浆蛋白外渗；另一个是后期反应，涉及嗜中性多形核白细胞浸润。当用BRL 10833（它抑制大鼠肥大细胞释放组胺并减少血浆蛋白外渗）改变即刻反应时，嗜中性粒细胞浸润并未减少。SRS-A拮抗剂FPL 55712也未能抑制嗜中性粒细胞浸润。β-肾上腺素能受体激动剂异丙肾上腺素和沙丁胺醇可减少嗜中性粒细胞浸润。异丙肾上腺素在抗原注射前给药时可抑制血浆蛋白外渗，但即使在抗原注射后大鼠血浆蛋白外渗已完成时给药，它仍能抑制嗜中性粒细胞浸润。普萘洛尔可逆转异丙肾上腺素诱导的对嗜中性粒细胞浸润的抑制作用。
