Smith H, Spicer B A, Ross J W
Int Arch Allergy Appl Immunol. 1977;54(5):414-21. doi: 10.1159/000231856.
Four compounds with H1 anti-histamine activity and four adrenoceptor stimulants, each given to rats prior to passive peritoneal anaphylaxis (PPA), inhibited extravasation of serum proteins into the peritoneal fluid at doses which had no effect on histamine release. In contrast, aminophylline and some non-steroidal anti-inflammatory agents inhibited extravasation only at doses which inhibited histamine releases they showed a similar type of avtivity to that of disodium cromoglycate (DSCG) and a nitroindanedione (BRL 10833), although they were much less potent. Predosing with DSCG reduced the potency of subsequent doses of DSCG, BRL 10833 and indomethacin, but not of aminophylline or phenylbutazone, and therefore DSCG, BRL 10833 and indomethacin may share a common pathway to produce activity. In the rat PPA system, no evidence was found for histamine 'feedback' inhibition of histamine release.
四种具有H1抗组胺活性的化合物和四种肾上腺素能受体兴奋剂，在被动腹膜过敏反应（PPA）前给予大鼠，在对组胺释放无影响的剂量下抑制血清蛋白向腹膜液的外渗。相比之下，氨茶碱和一些非甾体抗炎药仅在抑制组胺释放的剂量下抑制外渗，它们表现出与色甘酸钠二钠（DSCG）和一种硝基茚满二酮（BRL 10833）类似的活性类型，尽管它们的效力要低得多。预先给予DSCG会降低随后剂量的DSCG、BRL 10833和吲哚美辛的效力，但不会降低氨茶碱或保泰松的效力，因此DSCG、BRL 10833和吲哚美辛可能共享一条产生活性的共同途径。在大鼠PPA系统中，未发现组胺对组胺释放的“反馈”抑制作用的证据。
