Ross J W, Smith H, Spicer B A
Int Arch Allergy Appl Immunol. 1976;51(2):226-37. doi: 10.1159/000231595.
Following intraperitoneal sensitisation of rats with rat serum containing reaginic antibody, intravenous injection of blue dye and intraperitoneal challenge with antigen caused a release of histamine, slow-reacting substance of anaphylaxis (SRS-A) and dye into their peritoneal fluids. The times taken to reach peak concentrations after challenge were less than 2 min for histamine and between 5 and 10 min for SRS-A, whilst concentrations of dye were still increasing after 2 1/2 h. The amounts of histamine released by antigen were sufficient to account for about 60% of this extravasation of dye. Disodium cromoglycate (DSCG) and a nitroindanedione (BRL 10833) inhibited extravasation by inhibition of mediator release. BRL 10833, unlike DSCG, was active after oral administration, and for a given inhibition of histamine release it produced a greater effect on extravasation when given orally than when injected intraperitoneally.
用含有反应素抗体的大鼠血清对大鼠进行腹腔致敏后，静脉注射蓝色染料并腹腔注射抗原，会导致组胺、过敏反应慢反应物质（SRS - A）和染料释放到它们的腹腔液中。激发后达到峰值浓度的时间，组胺少于2分钟，SRS - A为5至10分钟，而2个半小时后染料浓度仍在增加。抗原释放的组胺量足以解释约60%的染料渗出。色甘酸钠（DSCG）和一种硝基茚二酮（BRL 10833）通过抑制介质释放来抑制渗出。与DSCG不同，BRL 10833口服后有活性，对于给定的组胺释放抑制作用，口服给药时对渗出的影响比腹腔注射时更大。
