抑肽酶对体外血栓弹力图的影响。

The effect of aprotinin on thrombelastography in vitro.

作者信息

Chalkiadis G A, Gibbs N M

机构信息

Department of Anaesthesia, Sir Charles Gairdner Hospital Nedlands, W.A.

出版信息

Anaesth Intensive Care. 1996 Oct;24(5):552-4. doi: 10.1177/0310057X9602400507.

DOI:10.1177/0310057X9602400507

PMID:8909664

Abstract

The effect of low dose (50 KIU/ml) and high dose (200 KIU/ml) aprotinin on standard thrombelastographic variables (r, K, alpha, MA) was examined in vitro using blood from forty ASA Class 1 patients. Both concentrations of aprotinin resulted in minor increases in r time above the normal range (P < 0.05). Aprotinin did not alter other thrombelastographic variables. The results indicate that aprotinin is a mild direct anticoagulant in vitro as assessed by thrombelastography.

摘要

使用40名ASA 1级患者的血液，在体外研究了低剂量（50 KIU/ml）和高剂量（200 KIU/ml）抑肽酶对标准血栓弹力图变量（r、K、α、MA）的影响。两种浓度的抑肽酶均导致r时间略高于正常范围（P < 0.05）。抑肽酶未改变其他血栓弹力图变量。结果表明，通过血栓弹力图评估，抑肽酶在体外是一种轻度直接抗凝剂。