Neely A N, Imwalle A R, Holder I A
Shriners Burns Institute, Cincinnati, Ohio, USA.
Burns. 1996 Nov;22(7):520-3. doi: 10.1016/0305-4179(96)00022-8.
Oedema, due to increased vascular leakage postburn, cases significant problems for burn patients. The purpose of this study was to determine if local application of a recombinant neutral endopeptidase (rNEP) would reduce the increased vascular permeability caused by a burn. In a guinea-pig model, a single treatment of rNEP given immediately postburn significantly decreased burn-induced plasma extravasation. This rNEP effect was dependent upon both the dosage of the peptidase and its enzymatic activity. Additional experiments were consistent with the rNEP acting partly by degrading bradykinin, a mediator of increased vascular permeability postburn. These findings suggest that further study of rNEP as a possible treatment for oedema is warranted.
烧伤后血管渗漏增加导致的水肿给烧伤患者带来了重大问题。本研究的目的是确定局部应用重组中性内肽酶（rNEP）是否会降低烧伤引起的血管通透性增加。在豚鼠模型中，烧伤后立即单次给予rNEP可显著减少烧伤诱导的血浆外渗。这种rNEP效应取决于肽酶的剂量及其酶活性。额外的实验表明，rNEP部分是通过降解缓激肽起作用的，缓激肽是烧伤后血管通透性增加的一种介质。这些发现表明，有必要进一步研究rNEP作为水肿可能的治疗方法。
