Carvajal H F, Brouhard B H, Linares H A
J Trauma. 1975 Nov;15(11):969-75. doi: 10.1097/00005373-197511000-00005.
Tiny (0.2% TBS), partial thickness, non-contact radiant heat burns in guinea pigs resulted, within 3 hours, in significant edema formation and protein leakage at the site of the injury. Areas of skin distant to the burn also showed an increase in water content but no protein leakage. Pretreatment of the animals with either chlorisondamine hydrochloride or a mixture of methysergide and chlorpheniramine significantly decreased postburn edema formation and protein leakage. Liquid emulsion autoradiography revealed that leakage of protein occurs primarily in the areas of skin adjacent to the panniculus carnosus. The studies suggest that: the increase in vascular permeability that occurs as a consequence of burn injuries is humorally mediated; albumin leakage is limited to the injured tissues; and histamine, serotonin, and presumably catecholamines play significant roles in the development of this phenomenon.
在豚鼠身上造成微小（占体表面积0.2%）的浅度、非接触性辐射热烧伤后，3小时内受伤部位出现明显的水肿形成和蛋白质渗漏。烧伤部位以外的皮肤区域含水量也有所增加，但无蛋白质渗漏。用盐酸氯异吲哚铵或麦角新碱与氯苯那敏的混合物对动物进行预处理，可显著减少烧伤后水肿形成和蛋白质渗漏。液体乳胶放射自显影显示，蛋白质渗漏主要发生在与腹直肌相邻的皮肤区域。这些研究表明：烧伤损伤导致的血管通透性增加是由体液介导的；白蛋白渗漏仅限于受伤组织；组胺、5-羟色胺以及可能的儿茶酚胺在这一现象的发生过程中起重要作用。
