在肾细胞癌中发现的膜结合中性芳基酰胺酶的胎盘形式。
Placental form of membrane-bound neutral arylamidase found in renal cell carcinoma.
作者信息
Hiwada K, Terao M, Kokubu T
出版信息
Clin Chim Acta. 1977 Sep 15;79(3):569-73. doi: 10.1016/0009-8981(77)90177-2.
A placental form of membrane-bound neutral arylamidase was found in the tissue of renal cell carcinoma. Membrane-bound neutral arylamidases from renal cell carcinoma, an intact part of the same kidney and placenta, had the same molecular weight (240 000) and were identical with respect to KM value and effect of inhibition by chelators or amino acids. Membrane-bound neutral arylamidase from renal carcinoma had the same electrophoretic mobility and heat stability as placental membrane-bound neutral arylamidase, but differed from kidney membrane-bound neutral arylamidase with respect to electrophoretic mobility, heat stability and susceptibility to urea inactivation. Results suggest the carcinoplacental alterations in membrane-bound neutral arylamidase isoenzyme in renal cell carcinoma.
在肾细胞癌组织中发现了一种胎盘形式的膜结合中性芳基酰胺酶。来自肾细胞癌、同一肾脏完整部分和胎盘的膜结合中性芳基酰胺酶具有相同的分子量（240000），并且在米氏常数以及螯合剂或氨基酸的抑制作用方面是相同的。来自肾癌的膜结合中性芳基酰胺酶与胎盘膜结合中性芳基酰胺酶具有相同的电泳迁移率和热稳定性，但在电泳迁移率、热稳定性和对尿素失活的敏感性方面与肾膜结合中性芳基酰胺酶不同。结果表明肾细胞癌中膜结合中性芳基酰胺酶同工酶存在癌胎盘改变。
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