Kläger S L, Whitworth J A, Downham M D
Department of Biological Sciences, Keele University, Staffordshire, UK.
Trop Med Int Health. 1996 Oct;1(5):581-9. doi: 10.1111/j.1365-3156.1996.tb00083.x.
Onchocerca volvulus nodules were removed from 77 fully compliant patients in a longitudinal study of ivermectin treatment in Sierra Leone. The patients had participated in a randomized controlled trial and received either 4 annual doses of ivermectin or 10 6-monthly doses over 6 years. Worms were examined 9 months after the last treatment for evidence of changes in morphology, viability and reproductivity. The findings were compared with results for the 2 groups obtained at earlier surveys of the same study population. Repeated treatment at 6 and 12-month intervals has resulted in a marked ageing of the male worm population profile and a significant reduction in the proportion of live female worms found in the nodules. In addition, there has been a reduction in reproductivity of 90% or more. However, most of the worms found were still alive and potentially fertile, underlining the need for the continuation of regular ivermectin treatment to maintain the benefits achieved.
在塞拉利昂进行的一项关于伊维菌素治疗的纵向研究中，从77名完全依从的患者身上摘除了盘尾丝虫结节。这些患者参与了一项随机对照试验，在6年时间里，要么每年接受4剂伊维菌素治疗，要么每6个月接受10剂治疗。在最后一次治疗9个月后检查蠕虫，以寻找形态、活力和繁殖力变化的证据。将这些结果与同一研究人群早期调查中这两组的结果进行比较。每隔6个月和12个月重复治疗已导致雄虫种群概况显著老化，结节中活雌虫的比例显著降低。此外，繁殖力降低了90%或更多。然而，发现的大多数蠕虫仍然存活且可能具有生育能力，这突出表明需要继续定期进行伊维菌素治疗以维持已取得的成效。
