Lundberg J O, Ehrén I, Jansson O, Adolfsson J, Lundberg J M, Weitzberg E, Alving K, Wiklund N P
Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden.
Urology. 1996 Nov;48(5):700-2. doi: 10.1016/S0090-4295(96)00423-2.
A role for nitric oxide (NO) has been suggested in inflammation and host defense. At higher concentrations, this gas shows cytotoxic effects that may be directed against microorganisms, tumor cells as well as host cells. The aim of the present study was to study the relationship between bladder mucosal inflammation and local production of NO.
We measured NO directly in the urinary bladder in patients with infectious cystitis, interstitial cystitis, irradiation cystitis, and cystitis induced by antitumor treatment with bacillus Calmette-Guérin. NO-free air was introduced into the bladder during cystoscopy. The air was aspirated after 5 minutes of incubation and injected into a chemiluminescence NO analyzer.
NO levels were 30 to 50 times higher in all varieties of cystitis as compared to controls.
NO may contribute to host-defense mechanisms in the bladder during bacterial infection and antitumor treatment. Direct measurement of gaseous NO in the urinary bladder seems to be an attractive diagnostic method for detection of mucosal inflammation.
一氧化氮（NO）在炎症和宿主防御中被认为发挥了作用。在较高浓度时，这种气体表现出细胞毒性作用，可能针对微生物、肿瘤细胞以及宿主细胞。本研究的目的是探讨膀胱黏膜炎症与局部NO产生之间的关系。
我们在感染性膀胱炎、间质性膀胱炎、放射性膀胱炎以及卡介苗抗肿瘤治疗诱导的膀胱炎患者的膀胱中直接测量NO。在膀胱镜检查期间，将无NO的空气引入膀胱。孵育5分钟后吸出空气，并注入化学发光NO分析仪。
与对照组相比，所有类型的膀胱炎中NO水平高出30至50倍。
在细菌感染和抗肿瘤治疗期间，NO可能有助于膀胱的宿主防御机制。直接测量膀胱中的气态NO似乎是检测黏膜炎症的一种有吸引力的诊断方法。
