Roberts E L, Sick T J
Department of Neurology, University of Miami, School of Medicine, FL 33136, USA.
Brain Res. 1996 Oct 7;735(2):339-42. doi: 10.1016/0006-8993(96)00925-0.
We investigated whether aging changed H+ homeostasis in hippocampal slices bathed in HEPES buffer. Intracellular pH in hippocampal slices from rats aged 26-27 months (7.06 +/- 0.02) was significantly lower compared with that in slices from rats aged 6-7 months (7.16 +/- 0.04). Age did not influence extracellular ph. Age-related reductions in intracellular pH may reflect altered pH regulation that potentially affects brain function and could contribute to the increased vulnerability of the aged brain to metabolic stress.
我们研究了衰老是否会改变浸泡在HEPES缓冲液中的海马切片中的H⁺稳态。26 - 27月龄大鼠海马切片的细胞内pH值（7.06±0.02）显著低于6 - 7月龄大鼠切片（7.16±0.04）。年龄不影响细胞外pH值。与年龄相关的细胞内pH值降低可能反映了pH调节的改变，这可能会影响脑功能，并可能导致老年大脑对代谢应激的易感性增加。
