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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Department of Biology, Kanebo Ltd, Osaka, Japan.

Clin Exp Pharmacol Physiol. 1996 Oct-Nov;23(10-11):890-2. doi: 10.1111/j.1440-1681.1996.tb01139.x.

Cortical spreading depression (CSD) was induced by direct current stimulation of the lateral frontal cortex in awake and freely moving rats. 2. Regional cerebral blood flow (rCBF) was continuously measured by a laser Doppler flowmeter using an acrylic cup which was chronically fixed on the surface of the cerebral cortex. Under the resting condition rCBF remained constant throughout the observation period and showed a high reproducibility. 3. rCBF increased to approximately 190% of control values during 1-3 min after CSD, and decreased to approximately 80% of control values, before returning to normal values 60 min after CSD. 4. These results are consistent with those found in anesthetized animals. This is the first study which has continuously monitored cortical hypoperfusion after CSD in awake and freely moving rats. The model is a useful system for studying migraine with aura.

通过对清醒自由活动的大鼠额叶外侧皮质进行直流电刺激来诱发皮质扩散性抑制（CSD）。2. 使用长期固定在大脑皮质表面的丙烯酸杯，通过激光多普勒血流仪连续测量局部脑血流量（rCBF）。在静息状态下，rCBF在整个观察期内保持恒定，并具有很高的重现性。3. CSD后1 - 3分钟内，rCBF增加至对照值的约190%，然后降至对照值的约80%，在CSD后60分钟恢复至正常值。4. 这些结果与在麻醉动物中发现的结果一致。这是第一项在清醒自由活动的大鼠中连续监测CSD后皮质灌注不足的研究。该模型是研究伴有先兆偏头痛的有用系统。

Department of Biology, Kanebo Ltd, Osaka, Japan.

Clin Exp Pharmacol Physiol. 1996 Oct-Nov;23(10-11):890-2. doi: 10.1111/j.1440-1681.1996.tb01139.x.

Cortical spreading depression (CSD) was induced by direct current stimulation of the lateral frontal cortex in awake and freely moving rats. 2. Regional cerebral blood flow (rCBF) was continuously measured by a laser Doppler flowmeter using an acrylic cup which was chronically fixed on the surface of the cerebral cortex. Under the resting condition rCBF remained constant throughout the observation period and showed a high reproducibility. 3. rCBF increased to approximately 190% of control values during 1-3 min after CSD, and decreased to approximately 80% of control values, before returning to normal values 60 min after CSD. 4. These results are consistent with those found in anesthetized animals. This is the first study which has continuously monitored cortical hypoperfusion after CSD in awake and freely moving rats. The model is a useful system for studying migraine with aura.

通过对清醒自由活动的大鼠额叶外侧皮质进行直流电刺激来诱发皮质扩散性抑制（CSD）。2. 使用长期固定在大脑皮质表面的丙烯酸杯，通过激光多普勒血流仪连续测量局部脑血流量（rCBF）。在静息状态下，rCBF在整个观察期内保持恒定，并具有很高的重现性。3. CSD后1 - 3分钟内，rCBF增加至对照值的约190%，然后降至对照值的约80%，在CSD后60分钟恢复至正常值。4. 这些结果与在麻醉动物中发现的结果一致。这是第一项在清醒自由活动的大鼠中连续监测CSD后皮质灌注不足的研究。该模型是研究伴有先兆偏头痛的有用系统。