Fabricius M, Lauritzen M
Department of General Physiology and Biophysics, University of Copenhagen, Denmark.
Brain Res. 1993 Feb 5;602(2):350-3. doi: 10.1016/0006-8993(93)90701-n.
Regional cerebral blood flow (rCBF) was examined following single episodes of cortical spreading depression (CSD) in rat brain after an intravenous bolus injection of [14C]iodoantipyrine. Cortical rCBF decreased to approximately 75% of control values during the first 60 min after CSD. This change was succeeded at 90-105 min by a small, transient flow increase. rCBF returned to normal at 120 min after CSD, and remained normal for the following 2 h. The same sequence of rCBF changes has been recorded in patients during migraine attacks. This study therefore supports the notion that CSD may serve as an animal model of migraine.
在大鼠脑内静脉推注[14C]碘安替比林后，对单次皮质扩散性抑制（CSD）发作后的局部脑血流量（rCBF）进行了检测。在CSD后的最初60分钟内，皮质rCBF降至对照值的约75%。在90 - 105分钟时，这种变化之后出现了一次短暂的小幅度血流增加。CSD后120分钟时rCBF恢复正常，并在随后的2小时内保持正常。在偏头痛发作期间的患者中也记录到了相同的rCBF变化序列。因此，本研究支持CSD可能作为偏头痛动物模型的观点。
