Hou Y, Guo Z, Li J, Wang P G
Department of Chemistry, University of Miami, Coral Gables, Florida 33124, USA.
Biochem Biophys Res Commun. 1996 Nov 1;228(1):88-93. doi: 10.1006/bbrc.1996.1620.
Seleno compounds such as selenocystamine and seleno-D, L-cystine were found to catalyze the decomposition of S-nitrosothiols (e.g. S-nitroso-glutathione and S-nitroso-N-acetyl-D, L-penicillamine) in the presence of different thiols (e.g. glutathione, N-acetyl-D-penicillamine and 2-mercaptoethanol), and liberate nitric oxide. It was also found that glutathione peroxidase itself can catalyze the decomposition of S-nitrosoglutathione without the presence of any thiol or H2O2.
已发现硒化合物，如硒代胱胺和硒代 - D，L - 胱氨酸，在不同硫醇（如谷胱甘肽、N - 乙酰 - D - 青霉胺和2 - 巯基乙醇）存在的情况下，能催化S - 亚硝基硫醇（如S - 亚硝基谷胱甘肽和S - 亚硝基 - N - 乙酰 - D，L - 青霉胺）的分解，并释放一氧化氮。还发现谷胱甘肽过氧化物酶本身在不存在任何硫醇或过氧化氢的情况下就能催化S - 亚硝基谷胱甘肽的分解。
