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肝硬化患者运动性加重的低氧血症和直立性低氧血症

Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis.

作者信息

Kennedy T C, Knudson R J

出版信息

Chest. 1977 Sep;72(3):305-9. doi: 10.1378/chest.72.3.305.

DOI:10.1378/chest.72.3.305
PMID:891282
Abstract

A syndrome characterized by hypoxemia aggravated by exercise, orthodeoxia, hypocapnia, and evidence of hyperdynamic circulation, but otherwise normal indices of pulmonary air flow, volume, and distribution of ventilation has been observed as an infrequent complication of hepatic cirrhosis. An illustrative case is described, the features of which support the presence of a shunt or shunt-like mechanism consisting of low-resistance vascular communications within the lung. We suggest that this may represent the existence of a hepatopulmonary syndrome analogous to the hepatorenal syndrome.

摘要

一种以运动时低氧血症加重、直立性低氧血症、低碳酸血症以及高动力循环证据为特征,但肺气流、容量和通气分布的其他指标正常的综合征,已被观察到是肝硬化的一种罕见并发症。本文描述了一个典型病例,其特征支持存在一种由肺内低阻力血管交通组成的分流或类似分流的机制。我们认为这可能代表存在一种类似于肝肾综合征的肝肺综合征。

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Exercise-aggravated hypoxemia and orthodeoxia in cirrhosis.肝硬化患者运动性加重的低氧血症和直立性低氧血症
Chest. 1977 Sep;72(3):305-9. doi: 10.1378/chest.72.3.305.
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[Study of the causes of the hypoxemia in hepatic cirrhosis. Arteriovenous shunts during muscular exercise of moderate intensity].[肝硬化低氧血症病因的研究。中等强度肌肉运动时的动静脉分流]
Minerva Med. 1966 Oct 27;57(86):3536-9.
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Pulmonary hypertension following hepatopulmonary syndrome in a patient with cirrhosis.一名肝硬化患者肝肺综合征后出现肺动脉高压。
J Hepatol. 1999 Aug;31(2):360-4. doi: 10.1016/s0168-8278(99)80236-0.
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An unusual cause of refractory hypoxemia in cirrhosis.
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The hepatopulmonary syndrome: new name, old complexities.肝肺综合征:新名称,旧难题。
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[Hepatopulmonary syndrome in liver cirrhosis].[肝硬化中的肝肺综合征]
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Hypoxemia in patients with liver cirrhosis.肝硬化患者的低氧血症
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Refractory hypoxemia during liver cirrhosis. Hepatopulmonary syndrome or "primary" pulmonary hypertension?
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[A case of severe hypoxemia due to a shunt-like effect accompanied with liver cirrhosis].[一例伴有肝硬化的分流样效应导致的严重低氧血症病例]
Nihon Kyobu Shikkan Gakkai Zasshi. 1987 Feb;25(2):251-6.

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