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肝硬化:中西医治疗现状与选择

Liver cirrhosis: current status and treatment options using western or traditional Chinese medicine.

作者信息

Zheng Shihao, Xue Chengyuan, Li Size, Zao Xiaobin, Li Xiaoke, Liu Qiyao, Cao Xu, Wang Wei, Qi Wenying, Du Hongbo, Zhang Peng, Ye Yongan

机构信息

Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, China.

Beijing University of Chinese Medicine, Beijing, China.

出版信息

Front Pharmacol. 2024 Jul 16;15:1381476. doi: 10.3389/fphar.2024.1381476. eCollection 2024.

Abstract

Liver cirrhosis arises from liver fibrosis and necroinflammation caused by various mechanisms of hepatic injury. It is a prevalent condition in clinical practice characterized by hepatocellular dysfunction, portal hypertension, and associated complications. Despite its common occurrence, the etiology and pathogenesis of liver cirrhosis remain incompletely understood, posing a significant health threat. Effective prevention of its onset and progression is paramount in medical research. Symptoms often include discomfort in the liver area, while complications such as sarcopenia, hepatic encephalopathy, ascites, upper gastrointestinal bleeding, and infection can arise. While the efficacy of Western medicine in treating liver cirrhosis is uncertain, Chinese medicine offers distinct advantages. This review explores advancements in liver cirrhosis treatment encompassing non-pharmacological and pharmacological modalities. Chinese medicine interventions, including Chinese medicine decoctions, Chinese patent medicines, and acupuncture, exhibit notable efficacy in cirrhosis reversal and offer improved prognoses. Nowadays, the combination of Chinese and Western medicine in the treatment of liver cirrhosis also has considerable advantages, which is worthy of further research and clinical promotion. Standardized treatment protocols based on these findings hold significant clinical implications.

摘要

肝硬化由各种肝损伤机制引起的肝纤维化和坏死性炎症发展而来。它是临床实践中一种常见病症,其特征为肝细胞功能障碍、门静脉高压及相关并发症。尽管肝硬化很常见,但其病因和发病机制仍未完全明确,对健康构成重大威胁。在医学研究中,有效预防其发生和进展至关重要。症状通常包括肝区不适,同时可能出现肌肉减少症、肝性脑病、腹水、上消化道出血和感染等并发症。虽然西医治疗肝硬化的疗效尚不确定,但中医具有明显优势。本综述探讨了肝硬化治疗方面的进展,包括非药物和药物治疗方式。中医干预措施,包括中药汤剂、中成药和针灸,在逆转肝硬化方面显示出显著疗效,并能改善预后。如今,中西医结合治疗肝硬化也具有相当大的优势,值得进一步研究和临床推广。基于这些研究结果的标准化治疗方案具有重要的临床意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c799/11286405/f9ab5a02e3b6/fphar-15-1381476-g001.jpg

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