Hicks C R, Chirila T V, Dalton P D, Clayton A B, Vijayasekaran S, Crawford G J, Constable I J
Lions Eye Institute, Nedlands, Western Australia.
Aust N Z J Ophthalmol. 1996 Aug;24(3):297-303. doi: 10.1111/j.1442-9071.1996.tb01597.x.
To develop a prototype artificial cornea and evaluate it in the rabbit model.
Hydrogel core-and-skirt keratoprostheses were made and were inserted as full-thickness implants covered with conjunctival flaps in the right eyes of eight rabbits.
Peroperative complications related to inadequate mechanical strength led to failure in the early postoperative period in three animals, one was euthanased for an unrelated reason and the remaining four have been successful for up to 16 weeks' follow-up.
Full-thickness implantation of an artificial cornea, analogous to penetrating keratoplasty, has been achieved in the rabbit model. Histological findings confirm that integration of the prosthesis with host tissue occurs. The main complications encountered in this preliminary series were related to inadequate strength of the sponge skirt of this prototype device. Work in our laboratories is now concentrated upon improving the mechanical qualities of the hydrogel skirt and on the enhancement of biointegration.
研发一种人工角膜原型并在兔模型中进行评估。
制作水凝胶芯-裙式角膜假体，并将其作为全层植入物插入八只兔子右眼，植入物上覆盖结膜瓣。
与机械强度不足相关的术中并发症导致三只动物在术后早期失败，一只因无关原因实施安乐死，其余四只成功随访长达16周。
在兔模型中已实现类似于穿透性角膜移植术的人工角膜全层植入。组织学结果证实假体与宿主组织发生整合。该初步系列中遇到的主要并发症与该原型装置海绵裙强度不足有关。我们实验室目前的工作集中在改善水凝胶裙的机械性能以及增强生物整合方面。
