Ganel A, Horoszowski H
Unit of Pediatric Orthopaedics, Sackler School of Medicine, Tel-Aviv University, Tel-Hashomer, Israel.
Clin Orthop Relat Res. 1996 Nov(332):179-83. doi: 10.1097/00003086-199611000-00024.
Twelve achondroplastic dwarfs underwent serial limb lengthening during childhood. All had repeated bilateral simultaneous elongation of their lower limbs. The height of these patients was plotted on growth curves for children with achondroplasia. The end results were evaluated after all patients reached skeletal maturity. Growth acceleration was seen in male patients with achondroplasia, but no such effect was seen in females. The female patients lost several centimeters as calculated from their predicted final height based on their preoperative growth curve and the centimeters gained by mechanical distraction. The authors' recommendation is to start limb elongation of male patients with achondroplasia at the age of 8 years or older, but to delay limb lengthening in female patients with achondroplasia until approximately 15 years of age to allow for maximal skeletal growth.
12名软骨发育不全性侏儒症患儿在儿童期接受了系列肢体延长手术。所有人都进行了双侧下肢的反复同步延长。将这些患者的身高绘制在软骨发育不全患儿的生长曲线上。在所有患者达到骨骼成熟后评估最终结果。软骨发育不全的男性患者出现了生长加速，但女性患者未出现这种情况。根据术前生长曲线和机械牵张获得的厘米数计算，女性患者比预测的最终身高矮了几厘米。作者建议，对于软骨发育不全的男性患者，应在8岁及以上开始肢体延长，但对于软骨发育不全的女性患者，应将肢体延长推迟至约15岁，以实现最大程度的骨骼生长。
