Ohizumi Y, Sasaki S, Shibusawa K, Ishikawa K, Ikemoto F
Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.
Biol Pharm Bull. 1996 Oct;19(10):1377-9. doi: 10.1248/bpb.19.1377.
We have reported previously that [8]-gingerol increased Ca(2+)-ATPase activity. Here we synthesized gingerol related compounds (AP-004, AP-005 and AP-015) and investigated the effects of gingerols ([6]-gingerol, [8]-gingerol and [10]-gingerol) and the synthesized compounds on the Ca(2+)-ATPase activity of sarcoplasmic reticulum (SR). The Ca(2+)-ATPase activity and the Ca(2+)-pumping activity increased by these compounds in a concentration-dependent manner. It is probable that both the o-methoxyphenol and hydrocarbon chain in the molecule of gingerol analogues are necessary for the activation of the Ca(2+)-pumping ATPase activity of SR.
我们之前报道过，[8]-姜酚可提高Ca(2+)-ATP酶活性。在此，我们合成了姜酚相关化合物（AP-004、AP-005和AP-015），并研究了姜酚（[6]-姜酚、[8]-姜酚和[10]-姜酚）及合成化合物对肌浆网（SR）Ca(2+)-ATP酶活性的影响。这些化合物可使Ca(2+)-ATP酶活性和Ca(2+)-泵浦活性呈浓度依赖性增加。姜酚类似物分子中的邻甲氧基苯酚和烃链可能对于激活SR的Ca(2+)-泵浦ATP酶活性都是必需的。
