心力衰竭的心律失常基因治疗。
Gene therapies for arrhythmias in heart failure.
机构信息
The Cardiovascular Research Center, Mount Sinai School of Medicine, New York, NY, USA,
出版信息
Pflugers Arch. 2014 Jun;466(6):1211-7. doi: 10.1007/s00424-014-1485-3. Epub 2014 Feb 26.
Abstract
In this article, we review recent advances in our understanding of arrhythmia mechanisms in the failing heart. We focus on changes in repolarization, conduction, and intracellular calcium cycling because of their importance to the vast majority of clinical arrhythmias in heart failure. We highlight recent efforts to combat arrhythmias using gene-based approaches that target ion channel, gap junction, and calcium cycling proteins. We further discuss the advantages and limitations associated with individual approaches.
摘要
在这篇文章中，我们回顾了我们对衰竭心脏中心律失常机制的理解的最新进展。我们专注于复极、传导和细胞内钙循环的变化，因为它们对心力衰竭中绝大多数临床心律失常都很重要。我们强调了最近使用基于基因的方法来对抗心律失常的努力，这些方法针对离子通道、缝隙连接和钙循环蛋白。我们进一步讨论了与个别方法相关的优点和局限性。
相似文献
1
Gene therapies for arrhythmias in heart failure.心力衰竭的心律失常基因治疗。
Pflugers Arch. 2014 Jun;466(6):1211-7. doi: 10.1007/s00424-014-1485-3. Epub 2014 Feb 26.
2
Gene therapy to restore electrophysiological function in heart failure.基因疗法恢复心力衰竭中的电生理功能。
Expert Opin Biol Ther. 2015 Jun;15(6):803-17. doi: 10.1517/14712598.2015.1036734. Epub 2015 Apr 12.
3
German Cardiac Society Working Group on Cellular Electrophysiology state-of-the-art paper: impact of molecular mechanisms on clinical arrhythmia management.德国心脏病学会细胞电生理学工作组最新论文：分子机制对临床心律失常管理的影响。
Clin Res Cardiol. 2019 Jun;108(6):577-599. doi: 10.1007/s00392-018-1377-1. Epub 2018 Oct 10.
4
Intracellular trafficking pathways of Cx43 gap junction channels.间隙连接蛋白 43 通道的细胞内运输途径。
Biochim Biophys Acta Biomembr. 2018 Jan;1860(1):40-47. doi: 10.1016/j.bbamem.2017.05.018. Epub 2017 May 30.
5
Dual gene therapy with SERCA1 and Kir2.1 abbreviates excitation without suppressing contractility.使用肌浆网钙ATP酶1（SERCA1）和内向整流钾通道2.1（Kir2.1）的双基因疗法可缩短兴奋时间而不抑制收缩性。
J Clin Invest. 2002 Feb;109(3):393-400. doi: 10.1172/JCI13359.
6
Arrhythmia mechanisms in the failing heart.衰竭心脏中的心律失常机制。
Pacing Clin Electrophysiol. 2008 Aug;31(8):1048-56. doi: 10.1111/j.1540-8159.2008.01134.x.
7
MicroRNA regulation of cardiac conduction and arrhythmias.微小 RNA 对心脏传导和心律失常的调控。
Transl Res. 2013 May;161(5):381-92. doi: 10.1016/j.trsl.2012.12.004. Epub 2012 Dec 27.
8
Developmental aspects of cardiac arrhythmogenesis.心脏心律失常发生的发展方面。
Cardiovasc Res. 2011 Jul 15;91(2):243-51. doi: 10.1093/cvr/cvr134. Epub 2011 May 12.
9
Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis.心脏复极化重塑：稳态反应如何导致心律失常的发生。
Cardiovasc Res. 2009 Feb 15;81(3):491-9. doi: 10.1093/cvr/cvn266. Epub 2008 Sep 30.
10
Arrhythmogenic Remodeling in the Failing Heart.心律失常性重构在心力衰竭中的作用。
Cells. 2021 Nov 17;10(11):3203. doi: 10.3390/cells10113203.
引用本文的文献
1
Pathophysiology of Calcium Mediated Ventricular Arrhythmias and Novel Therapeutic Options with Focus on Gene Therapy.钙介导性心室心律失常的病理生理学与以基因治疗为重点的新型治疗选择。
Int J Mol Sci. 2019 Oct 24;20(21):5304. doi: 10.3390/ijms20215304.
2
Gene therapy to restore electrophysiological function in heart failure.基因疗法恢复心力衰竭中的电生理功能。
Expert Opin Biol Ther. 2015 Jun;15(6):803-17. doi: 10.1517/14712598.2015.1036734. Epub 2015 Apr 12.
3
Toward microendoscopy-inspired cardiac optogenetics in vivo: technical overview and perspective.迈向体内微内镜启发的心脏光遗传学：技术概述与展望
J Biomed Opt. 2014 Aug;19(8):080701. doi: 10.1117/1.JBO.19.8.080701.
本文引用的文献
1
Long-term effects of AAV1/SERCA2a gene transfer in patients with severe heart failure: analysis of recurrent cardiovascular events and mortality.AAV1/SERCA2a 基因转导治疗严重心力衰竭患者的长期疗效：心血管事件再发和死亡率分析。
Circ Res. 2014 Jan 3;114(1):101-8. doi: 10.1161/CIRCRESAHA.113.302421. Epub 2013 Sep 24.
2
Designer gap junctions that prevent cardiac arrhythmias.设计防止心律失常的间隙连接。
Trends Cardiovasc Med. 2013 Feb;23(2):33-8. doi: 10.1016/j.tcm.2012.08.008. Epub 2012 Dec 13.
3
Targeted sarcoplasmic reticulum Ca2+ ATPase 2a gene delivery to restore electrical stability in the failing heart.靶向肌浆网 Ca2+-ATP 酶 2a 基因转导恢复衰竭心脏的电稳定性。
Circulation. 2012 Oct 23;126(17):2095-104. doi: 10.1161/CIRCULATIONAHA.111.071480. Epub 2012 Sep 27.
4
Connexin43 gene transfer reduces ventricular tachycardia susceptibility after myocardial infarction.缝隙连接蛋白 43 基因转染减少心肌梗死后室性心动过速易感性。
J Am Coll Cardiol. 2012 Sep 18;60(12):1103-10. doi: 10.1016/j.jacc.2012.04.042. Epub 2012 Aug 8.
5
Gene therapy for ventricular tachyarrhythmias.心室性心动过速的基因治疗。
Gene Ther. 2012 Jun;19(6):600-5. doi: 10.1038/gt.2012.35. Epub 2012 Apr 26.
6
Calcium Upregulation by Percutaneous Administration of Gene Therapy in Cardiac Disease (CUPID): a phase 2 trial of intracoronary gene therapy of sarcoplasmic reticulum Ca2+-ATPase in patients with advanced heart failure.经皮基因治疗增强心肌钙（CUPID）：晚期心力衰竭患者冠状动脉内肌浆网 Ca2+-ATP 酶基因治疗的 2 期试验。
Circulation. 2011 Jul 19;124(3):304-13. doi: 10.1161/CIRCULATIONAHA.111.022889. Epub 2011 Jun 27.
7
SERCA2a gene transfer decreases sarcoplasmic reticulum calcium leak and reduces ventricular arrhythmias in a model of chronic heart failure.肌浆网钙 ATP 酶 2a 基因转导减少慢性心力衰竭模型中的肌浆网钙渗漏并减少室性心律失常。
Circ Arrhythm Electrophysiol. 2011 Jun;4(3):362-72. doi: 10.1161/CIRCEP.110.961615. Epub 2011 Mar 15.
8
Gene therapy strategies for cardiac electrical dysfunction.心脏电功能障碍的基因治疗策略。
J Mol Cell Cardiol. 2011 May;50(5):759-65. doi: 10.1016/j.yjmcc.2010.07.022. Epub 2010 Aug 7.
9
Targeted SERCA2a gene expression identifies molecular mechanism and therapeutic target for arrhythmogenic cardiac alternans.靶向 SERCA2a 基因表达鉴定心律失常性心脏交替的分子机制和治疗靶点。
Circ Arrhythm Electrophysiol. 2009 Dec;2(6):686-94. doi: 10.1161/CIRCEP.109.863118.
10
Mechanoelectrical remodeling and arrhythmias during progression of hypertrophy.机械电重构与肥厚进展过程中的心律失常。
FASEB J. 2010 Feb;24(2):451-63. doi: 10.1096/fj.09-136622. Epub 2009 Oct 13.
Zotero 插件