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[人类外周血淋巴细胞中的自发染色体畸变]

[Spontaneous chromosome aberrations in the lymphocytes of human peripheral blood].

作者信息

Ivanov B, Praskova L, Mileva M, Bulanova M, Georgieva I

出版信息

Eksp Med Morfol. 1977;16(2):80-5.

PMID:891453
Abstract

The authors carried out cytogenetic studies on lymphocytes from human peripheral blood of 105 persons--49 women and 56 men in order to examine spontaneous frequency of the structural chromosomal abberations in the somatic cells. There were 191 cells with abberations (1,17%), out of 16,267 analyzed metaphasic plates. They found 0,39% of chromatid fragments, 0,71% of chromosomal fragments, 0,06% dicentricets, 0,01% of symetric and asymetric chromatid exchanges and 0,006% of rings. There were no statistically significant differences in the discovery of the spontaneous abberations in the examined persons at various age and sex.

摘要

作者对105人的外周血淋巴细胞进行了细胞遗传学研究,其中49名女性和56名男性,目的是检测体细胞中染色体结构畸变的自发频率。在16267个分析的中期相中,有191个细胞出现畸变(1.17%)。他们发现染色单体片段占0.39%,染色体片段占0.71%,双着丝粒占0.06%,对称和不对称染色单体交换占0.01%,环状染色体占0.006%。在所检查的不同年龄和性别的人群中,自发畸变的发现没有统计学上的显著差异。

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