Nevitt G J, Hutchinson P E
Department of Dermatology, Leicester Royal Infirmary, U.K.
Br J Dermatol. 1996 Oct;135(4):533-7.
The prevalence of psoriasis in a defined semi-urban general practice population of 5395 was estimated by means of a postal questionnaire, describing the features of psoriasis followed by physical examination of positive responders, and by a practice disease register, which directly identified psoriatic patients. A point prevalence of 1.48% was found based on examination at the time of study with an equal sex distribution. The mean age of development of the disease was 33 years. At the time of examination, the disease was mild in most patients (mean PASI 2.87). However, there was evidence of marked variability in severity within individuals with time. At some stage, 60% of individuals had required referral to a consultant dermatologist, and approximately 50% of these had received second-line, i.e. non-topical, treatments. Approximately 25% of patients had been in remission at some stage. Forty-one per cent of patients were aware that psoriasis was a genetically determined disease and 37% thought that stress was an exacerbating factor. Seventy per cent of patients were aware that the condition was not curable, but 63% thought that treatment was worthwhile. Fifty-three per cent described themselves as 'bothered' by the appearance of the condition. This concern was positively (and inversely) related to current age, and to stress as an exacerbating factor, but not to sex, PASI, duration of psoriasis, previous hospital referral, or the presence of pruritus. In this study of psoriasis in the community, the findings, particularly in relation to patients' attitude to the disease, disease severity, fluctuation in severity and referral requirements, are of potential interest in health care planning.
通过邮政问卷调查估计了5395名半城市普通人群中银屑病的患病率，问卷描述了银屑病的特征，随后对阳性应答者进行体格检查，并通过一份实践疾病登记册直接识别银屑病患者。基于研究时的检查发现点患病率为1.48%，男女分布均等。该疾病的平均发病年龄为33岁。在检查时，大多数患者的病情较轻（平均银屑病面积和严重程度指数为2.87）。然而，有证据表明个体病情严重程度随时间有明显变化。在某个阶段，60%的个体需要转诊至皮肤科顾问医生处，其中约50%接受了二线治疗，即非局部治疗。约25%的患者在某个阶段病情缓解。41%的患者知道银屑病是一种由基因决定的疾病，37%的患者认为压力是一个加重因素。70%的患者知道该病无法治愈，但63%的患者认为治疗是值得的。53%的患者表示因该病的外观而“困扰”。这种困扰与当前年龄呈正相关（与压力作为加重因素呈负相关），但与性别、银屑病面积和严重程度指数、银屑病病程、既往住院转诊或瘙痒的存在无关。在这项社区银屑病研究中，这些发现，特别是与患者对疾病的态度、疾病严重程度、严重程度波动和转诊需求相关的发现，对医疗保健规划具有潜在意义。
