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应用丁酸梭菌（M 55）后，131碘脱氧尿苷在肿瘤中的掺入增强。肿瘤阳性闪烁显像定位的动物实验。

Enhancement of incorporation of 131iododeoxyuridine into tumors after application of Clostridium oncolyticum s. butyricum (M 55). Animal experiments on positive scintigraphic localization of tumors.

作者信息

Volm M, Gerick D, Schuhmacher J, Wayss K

出版信息

Eur J Nucl Med. 1977 Jun 30;2(2):117-20. doi: 10.1007/BF00253684.

DOI:10.1007/BF00253684
PMID:891556
Abstract

The application of spores of the bacterium Clostridium oncolyticum s. butyricum (M 55) results in an increased incorporation of 131Iododeoxyuridine in tumors (amelanotic melanoma Fortner III of the golden hamster and Brown-Pearce carcinoma of the rabbit). This leads to an improved scintigraphic demonstration of the tumors.

摘要

溶瘤丁酸梭状芽孢杆菌（M 55）的孢子应用于肿瘤（金黄仓鼠的无黑色素黑素瘤Fortner III和兔的Brown-Pearce癌）后，可使肿瘤中131碘脱氧尿苷的掺入增加。这导致肿瘤的闪烁显像显示得到改善。

相似文献

1
Enhancement of incorporation of 131iododeoxyuridine into tumors after application of Clostridium oncolyticum s. butyricum (M 55). Animal experiments on positive scintigraphic localization of tumors.应用丁酸梭菌（M 55）后，131碘脱氧尿苷在肿瘤中的掺入增强。肿瘤阳性闪烁显像定位的动物实验。
Eur J Nucl Med. 1977 Jun 30;2(2):117-20. doi: 10.1007/BF00253684.
2
[Investigations on the characterization of a clostridial strain for tumour diagnosis (author's transl)].[用于肿瘤诊断的梭菌菌株特性研究（作者译）]
Zentralbl Bakteriol A. 1980 Feb;246(1):80-97.
3
[Application of the serological clostridium assay in tumour diagnostics (author's transl)].
Z Erkr Atmungsorgane. 1980;155(3):292-304.
4
[Tumor hyperthermia using high frequency for increase of oncolysis by clostridium butyricum (M 55)].[利用高频进行肿瘤热疗以增强丁酸梭菌（M 55）的溶瘤作用]
Strahlentherapie. 1976 Dec;152(6):537-41.
5
Delineation of a transplanted malignant melanoma with indium-111-labeled porphyrin.用铟-111标记的卟啉描绘移植的恶性黑色素瘤。
J Nucl Med. 1985 Jul;26(7):756-60.
6
[The use of clostridial antigens for a serological and autoradiographical early diagnosis of tumours (author's transl)].[利用梭菌抗原进行肿瘤的血清学和放射自显影早期诊断（作者译）]
Zentralbl Bakteriol Orig A. 1978 Dec;242(4):512-6.
7
[Therapeutic studies of Clostridium butyricum spores, cyclophosphamide and prednisolone in amelanotic melanoma in Syrian gold hamsters].[丁酸梭菌孢子、环磷酰胺和泼尼松龙对叙利亚金黄仓鼠无黑色素黑色素瘤的治疗研究]
Dermatol Monatsschr. 1973 Dec;159(12):1089-94.
8
[ON DIAGNOSIS OF LIVER TUMORS WITH AU198 (EXPERIMENTAL STUDY)].[用金-198诊断肝脏肿瘤（实验研究）]
Med Radiol (Mosk). 1964 Jan;9:42-7.
9
Increase in 131iodo-deoxyuridine incorporation in tumors after application of Clostridia.应用梭状芽孢杆菌后肿瘤中131碘脱氧尿苷掺入量增加。
Naturwissenschaften. 1974 Oct;61(10):458-9. doi: 10.1007/BF00597217.
10
[Tumor localization in vivo on the basis of scintigraphic detection of clostridium rods by means of 131J-labeled antibodies and F(ab')2 antibody fragments].[通过131J标记抗体和F(ab')2抗体片段对梭状芽孢杆菌进行闪烁扫描检测，在体内进行肿瘤定位]
Z Exp Chir. 1979 Aug;12(4):209-15.

本文引用的文献

1
Studies in the mouse of the pharmacology of 5-iododeoxyuridine, an analogue of thymidine.对胸腺嘧啶核苷类似物5-碘脱氧尿苷在小鼠体内的药理学研究。
Biochem Pharmacol. 1960 May;3:110-21. doi: 10.1016/0006-2952(60)90027-7.
2
[Oncolysis experiments with apathogenic, anaerobic spore suspensions on the Ehrlich tumor of the mouse].[用无致病性厌氧芽孢悬液对小鼠艾氏瘤进行溶瘤实验]
Z Krebsforsch. 1959;63:63-74.
3
[EXPERIMENTS WITH EHRLICH ASCITES TUMOR CELLS OF MICE AND THE CAUSATIVE AGENT OF TETANUS. I. TETANUS MORTALITY OF LABORATORY ANIMALS EXPOSED TO VARIOUS PRETREATMENT METHODS].
[小鼠艾氏腹水癌细胞与破伤风病原体的实验。I. 接受各种预处理方法的实验动物的破伤风死亡率]
Acta Biol Med Ger. 1965;14:52-70.
4
ONCOLYSIS BY CLOSTRIDIA. V. TRANSPLANTED TUMORS OF THE HAMSTER.梭菌溶瘤作用。V. 仓鼠移植瘤
Cancer Res. 1964 Feb;24:239-42.
5
PREPARATION OF VERY HIGH SPECIFIC ACTIVITY IODODEOXYURIDINE, IODOURIDINE AND IODOURACIL, LABELLED WITH IODINE-125, -131 OR -132.用碘 - 125、 - 131或 - 132标记的高比活度碘脱氧尿苷、碘尿苷和碘尿嘧啶的制备
Nature. 1963 Oct 5;200:65-6. doi: 10.1038/200065a0.
6
The distribution and fate of iododeoxycytidine in the mouse and rat.
Cancer Res. 1962 Nov;22:1257-64.
7
Localization of the vegetative form of Clostridium tetani in mouse tumors following intravenous spore administration.静脉注射破伤风梭菌芽孢后，破伤风梭菌营养体在小鼠肿瘤中的定位。
Cancer Res. 1955 Aug;15(7):473-8.
8
Reutilization of 131I-5-iodo-2'-deoxyuridine as compared to 3H-thymidine in mouse duodenum and mammary tumor.与³H-胸腺嘧啶核苷相比，¹³¹I-5-碘-2'-脱氧尿苷在小鼠十二指肠和乳腺肿瘤中的再利用情况。
J Natl Cancer Inst. 1970 Apr;44(4):827-40.
9
Incorporation of 131 iododeoxyuridine into the DNA of tumour-bearing rats after partial synchronization as a tool in scintigraphic tumour localization.部分同步化后将131碘脱氧尿苷掺入荷瘤大鼠的DNA中作为肿瘤闪烁定位的一种手段。
Nucl Med (Stuttg). 1974 Jan 15;12(4):309-19.
10
[Serological studies using clostridial spores for tumor diagnosis. I. Transplantable tumors in rats and hamsters].[利用梭菌孢子进行肿瘤诊断的血清学研究。I. 大鼠和仓鼠的可移植肿瘤]
Arch Geschwulstforsch. 1973;41(1):12-7.