Sugaya N, Kusumoto N, Suzuki Y, Nerome R, Nerome K
Department of Paediatrics, Nippon Kokan Hospital, Kawasaki, Japan.
J Med Virol. 1996 Oct;50(2):120-5. doi: 10.1002/(SICI)1096-9071(199610)50:2<120::AID-JMV4>3.0.CO;2-C.
During the mixed epidemic caused by influenza A (H3N2) and B in the 1992-1993 season in Japan, large sequential outbreaks occurred in an institution for mentally handicapped people where none of the residents or staff members had been immunized. During the influenza A outbreak (A/ Beijing/32/92-like strain) in January, 37.0% of the residents (85/230) and 31.4% of the staff (75/239) had an influenza-like illness. During the influenza B outbreak (B/Panama/45/90- and B/Beijing/184/ 93-like strain) in late February, 59.0% of the residents and 24.3% of the staff had an influenza-like illness. As many as 25.2% of the residents had two episodes of influenza-like illness during the season, as opposed to only 5.4% of the staff members. Mixed epidemics probably have a severe impact on institutionalized high-risk people, adversely affecting them almost twice as much as influenza epidemics caused by a single virus.
在1992 - 1993年日本甲型（H3N2）和乙型流感混合流行期间，一所智障人士机构发生了大规模的连续性疫情，该机构内的居民和工作人员均未接种疫苗。在1月份的甲型流感疫情（A/北京/32/92样毒株）期间，37.0%的居民（85/230）和31.4%的工作人员（75/239）出现了流感样疾病。在2月下旬的乙型流感疫情（B/巴拿马/45/90和B/北京/184/93样毒株）期间，59.0%的居民和24.3%的工作人员出现了流感样疾病。该季节多达25.2%的居民出现了两次流感样疾病发作，而工作人员中这一比例仅为5.4%。混合疫情可能对机构内的高危人群产生严重影响，对他们的不利影响几乎是单一病毒引起的流感疫情的两倍。
