Yamashita K, Yonezawa K, Izumisawa Y, Kotani T
Department of Veterinary Surgery I, School of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
J Vet Med Sci. 1996 Oct;58(10):1049-52. doi: 10.1292/jvms.58.10_1049.
The antagonistic effects of atipamezole (20, 40, 60, 80, and 100 micrograms/kg i.v.) on medetomidine (10 micrograms/kg i.v.)-induced sedation were evaluated in horses. Although 20 and 40 micrograms/kg of atipamezole were not sufficient to reverse the sedation, 60 micrograms/kg did effectively reverse the sedation. Atipamezole at 80 micrograms/kg was more potent, and significantly shortened the duration of sedation without any apparent side effects, but a higher dose of 100 micrograms/kg was not more effective than 80 micrograms/kg. The possible use of atipamezole as a reversal agent may enhance the value and availability of medetomidine as a chemical restraint agent in horses.
在马身上评估了阿替美唑（静脉注射剂量为20、40、60、80和100微克/千克）对美托咪定（静脉注射剂量为10微克/千克）诱导的镇静作用的拮抗效果。虽然20和40微克/千克的阿替美唑不足以逆转镇静作用，但60微克/千克确实有效地逆转了镇静作用。80微克/千克的阿替美唑效力更强，显著缩短了镇静持续时间且无任何明显副作用，但100微克/千克的更高剂量并不比80微克/千克更有效。阿替美唑作为一种逆转剂的可能用途可能会提高美托咪定作为马的化学保定剂的价值和可用性。
