Schiffer J, Walach N, Lushkov G, Nyska A, Gur R, Pollak L
Department of Neurosurgery, Assaf Harofeh Medical Center, Zerifin, Israel.
Neurol Res. 1996 Oct;18(5):454-6. doi: 10.1080/01616412.1996.11740451.
The effect of cisplatinum as a potential radiosensitizer in brain tumors is controversial. We examined the effect of the combination of cisplatinum with radiation compared to radiation alone in rabbits' brain. All rabbits were irradiated and cisplatinum was injected intravenously into part of them. Therapeutic doses of cisplatinum and irradiation were given. The rabbits were euthanised at different intervals according to protocol. The general clinical and neurological condition of the rabbits was unaffected, and histopathological examination of the rabbit's brain was normal. The purpose of this study was to establish the effect of cisplatinum followed by cranial irradiation in therapeutic doses to the normal rabbit's brain.
顺铂作为脑肿瘤潜在放射增敏剂的效果存在争议。我们研究了顺铂与放疗联合使用相较于单纯放疗对兔脑的影响。所有兔子均接受了照射，部分兔子静脉注射了顺铂。给予了顺铂和照射的治疗剂量。按照方案在不同时间间隔对兔子实施安乐死。兔子的一般临床和神经状况未受影响，兔脑的组织病理学检查结果正常。本研究的目的是确定给予治疗剂量的顺铂后再进行颅脑照射对正常兔脑的影响。
