Walach N, Lushkov G, Nyska A, Gur R, Pollak L, Schiffer J
Department of Oncology, Assaf Harofeh Medical Center, Affiliated to Sackler Faculty of Medicine, Tel Aviv University, Israel.
Neurol Res. 1997 Apr;19(2):216-8. doi: 10.1080/01616412.1997.11740798.
In former studies of intracarotid and intravenous administration of cisplatinum, separate and combined with brain irradiation, we found no cerebral damage. In this study, gradually increasing high doses (above the therapeutic ones) of cisplatinum were administered intravenously to one series of rabbits and increasing high amounts of irradiation (above the therapeutic amounts) were given to another series. Although the rabbits that received highest doses of irradiation developed areas of alopecia and skin ulcers on the head, the general clinical and histopathologic examination of the rabbits' brains in both series was normal. The purpose of this study was to establish the effects of high doses of intravenous cisplatinum and irradiation on the rabbits brains.
在之前关于颈内动脉和顺铂静脉给药的研究中，单独给药以及与脑部放疗联合给药时，我们均未发现脑损伤。在本研究中，对一组兔子静脉注射逐渐增加的高剂量（高于治疗剂量）顺铂，对另一组兔子给予逐渐增加的高剂量（高于治疗剂量）放疗。尽管接受最高剂量放疗的兔子头部出现了脱发区和皮肤溃疡，但两组兔子大脑的一般临床和组织病理学检查均正常。本研究的目的是确定高剂量静脉注射顺铂和放疗对兔子大脑的影响。
