肾上腺素能激动剂及其拮抗剂对硬蜱离体唾液腺的影响。

The influence of adrenergic agonists and their antagonists on isolated salivary glands of ixodid ticks.

作者信息

Kaufman W R

出版信息

Eur J Pharmacol. 1977 Sep 1;45(1):61-8. doi: 10.1016/0014-2999(77)90058-9.

Abstract

Various drugs elicit fluid secretion by isolated salivary glands of two species of ixodid ticks (Dermacentor andersoni Stiles and Amblyomma hebraeum Koch). Among catecholamines, the following order of potency was observed: dopamine, epinine, noradrenaline = adrenaline and isoprenaline. The following drugs, in order of potency, were also agonists on this preparation: ergonovine, ergotamine, 6-hydroxydopamine, apomorphine, phenylephrine, norphenylephrine, beta-phenylethylamine, tyramine, D, L-dopa and octopamine. Nialamide increased the response to near-threshold concentrations of dopamine but had no intrinsic activity. Dopamine-induced secretion was depressed by phenoxybenzamine, alpha-flupenthixol, phentolamine, propranolol and dichloroisoprenaline, but only at conce,trations 10- to 1000-fold that of the agonist. Pimozide and spiperone (10(-6) M) augmented the maximum response of dopamine. The tick salivary gland, thus appears to contain one or several receptors differing pharmacologically from mammalian alpha-adrenergic, beta-adrenergic and dopamine receptors.

摘要

多种药物可引起两种硬蜱（安德逊革蜱和希伯来花蜱）离体唾液腺的液体分泌。在儿茶酚胺类药物中，观察到以下效力顺序：多巴胺、去甲肾上腺素、去甲肾上腺素 = 肾上腺素和异丙肾上腺素。以下药物按效力顺序在该制剂上也是激动剂：麦角新碱、麦角胺、6-羟基多巴胺、阿扑吗啡、去氧肾上腺素、去甲去氧肾上腺素、β-苯乙胺、酪胺、D，L-多巴和章鱼胺。尼亚酰胺增加了对接近阈浓度多巴胺的反应，但没有内在活性。多巴胺诱导的分泌受到苯氧苄胺、α-氟哌噻吨、酚妥拉明、普萘洛尔和二氯异丙肾上腺素的抑制，但仅在激动剂浓度的10至1000倍时才起作用。匹莫齐特和螺哌隆（10(-6) M）增强了多巴胺的最大反应。因此，蜱唾液腺似乎含有一种或几种在药理学上与哺乳动物α-肾上腺素能、β-肾上腺素能和多巴胺受体不同的受体。