Barker R
National Hospital for Neurology and Neurosurgery, London, U.K.
Rev Neurosci. 1996 Jul-Sep;7(3):187-214. doi: 10.1515/revneuro.1996.7.3.187.
The tachykinins are a family of undecapeptides that are widely distributed throughout the body, including the central nervous system (CNS). They have several well defined roles in non-CNS sites as well as in the dorsal horn, where they are involved in the transmission of nociceptive information. However their function(s) in other CNS sites is unclear, but there is some evidence that they function as neuromodulators rather than neurotransmitters. This neuromodulation includes a possible role in maintaining the integrity of neuronal populations, analogous to the functions of neurotrophic factors. This review critically evaluates the role of tachykinins as neurotrophic factors, with particular reference to the common neurodegenerative diseases of the CNS.
速激肽是一类十一肽家族，广泛分布于全身，包括中枢神经系统（CNS）。它们在非中枢神经系统部位以及背角具有多种明确的作用，在背角参与伤害性信息的传递。然而，它们在中枢神经系统其他部位的功能尚不清楚，但有一些证据表明它们作为神经调质而非神经递质发挥作用。这种神经调节包括在维持神经元群体完整性方面可能发挥的作用，类似于神经营养因子的功能。本综述批判性地评估了速激肽作为神经营养因子的作用，尤其参考了中枢神经系统常见的神经退行性疾病。
