Hess G, Shih J W, Arnold W, Gerin J L, zum Büschenfelde K H
J Immunol. 1979 Sep;123(3):1189-94.
The present paper describes the demonstration of d, y, w, and r HBsAg determinants in one serum. It was shown that there are two populations of HBsAg particles: HBsAg/ad and HBsAg/ady. All complete Dane particles were of subtype HBsAg/ady. Further characterization of HBsAg/ady particles did not reveal morphologic differences when they were compared with HBsAg/ad and HBsAg/ay particles. An HBsAg/ady phenotype may be the result of a double infection with hepatitis B viruses or exchanges of DNA sequences that determine HBsAg/ay and HBsAg/ad to form a new genotype.
本文描述了在一份血清中对d、y、w和r HBsAg决定簇的鉴定。结果显示存在两种HBsAg颗粒群体：HBsAg/ad和HBsAg/ady。所有完整的丹氏颗粒均为HBsAg/ady亚型。与HBsAg/ad和HBsAg/ay颗粒相比，对HBsAg/ady颗粒的进一步特征分析未发现形态学差异。HBsAg/ady表型可能是由乙型肝炎病毒双重感染或决定HBsAg/ay和HBsAg/ad的DNA序列交换形成新基因型的结果。
