对乙肝表面抗原（HBsAg）阳性血液透析患者血清浓缩物中 Dane 颗粒的检测。
Tests for Dane particles in serum concentrates of HBsAg positive hemodialysis patients.
作者信息
Hess G, Arnold W, Koesters W, Meyer zum Büschenfelde K H
出版信息
Clin Nephrol. 1979 Jan;11(1):18-22.
The present study was undertaken to assess the infectivity of sera from HBsAg positive hemodialysis patients by measuring HBeAg, DNA polymerase activity and Dane particle associated HBcAg. Of 33 sera tested 25 were positive for at least one of these tests for Dane particles, indicating that most HBsAg positive hemodialysis patients are highly infectious. The demonstration of DNA polymerase activity in serum concentrates was proven to be the most sensitive assay for the detection and quantitation of Dane particles in serum. We conclude from our results that HBsAg positive hemodialysis patients should be treated in separate units and be served by staff who are either anti-HBs positive or HBsAg carriers.
本研究旨在通过检测HBeAg、DNA聚合酶活性以及与Dane颗粒相关的HBcAg，评估HBsAg阳性血液透析患者血清的传染性。在检测的33份血清中，有25份至少一项针对Dane颗粒的检测呈阳性，这表明大多数HBsAg阳性血液透析患者具有高度传染性。血清浓缩物中DNA聚合酶活性的检测被证明是检测和定量血清中Dane颗粒最敏感的方法。我们从结果中得出结论，HBsAg阳性血液透析患者应在单独的病房接受治疗，且应由抗-HBs阳性或HBsAg携带者的工作人员提供护理。
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