乙肝表面抗原（HBsAg）携带者血清中e抗原或抗体检测与HBsAg相关颗粒电子显微镜形态之间的相关性。
Correlations between the detection of e antigen or antibody and electron microscopic pattern of hepatitis B surface antigen (HBsAg) associated particles in the serum of HBsAg carriers.
作者信息
Trepo C, Bird R G, Zuckerman A J
出版信息
J Clin Pathol. 1977 Mar;30(3):216-20. doi: 10.1136/jcp.30.3.216.
The distribution of HBsAg associated particles, especially the presence of Dane particles, was studied by electron microscopy in coded sera of 68 chronic HBsAg carriers. Results were correlated with the detection of eAg or Ab and clinical diagnosis. Sera from haemodialysis and chronic hepatitis patients showed a high prevalence of e antigenaemia (9/13, 69-2% and 8/19, 42-1%) and Dane particles (11 and 16 respectively, 84%). By contrast, out of 36 chronic asymptomatic carriers of HBsAg, 28 (77-7%) were positive for e antibody but only 1 (2-7%) had eAg. Dane particles were found in 13/36 (36-1%). A statistically significant correlation was observed between the detection of eAg and the presence of Dane particles (94-4%) in the serum. However, Dane particles were still observed in 10/28 (35-7%) of anti-e positive sera. The data suggest that eAg may be linked to complete HB virions.
通过电子显微镜对68例慢性HBsAg携带者编码血清中HBsAg相关颗粒的分布，尤其是大球形颗粒的存在情况进行了研究。结果与e抗原或抗体的检测及临床诊断相关。血液透析患者和慢性肝炎患者的血清中e抗原血症（分别为9/13，69.2%和8/19，42.1%）及大球形颗粒（分别为11个和16个，84%）的患病率较高。相比之下，在36例慢性无症状HBsAg携带者中，28例（77.7%）e抗体呈阳性，但只有1例（2.7%）有e抗原。在13/36（36.1%）的携带者中发现了大球形颗粒。血清中e抗原的检测与大球形颗粒的存在（94.4%）之间存在统计学显著相关性。然而，在10/28（35.7%）的抗e阳性血清中仍观察到了大球形颗粒。数据表明，e抗原可能与完整的乙肝病毒颗粒有关。
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