Wooten M D, Jasin H E
Department of Internal Medicine, University of Arkansas for Medical Sciences, Little Rock 72205, USA.
Semin Arthritis Rheum. 1996 Oct;26(2):564-74. doi: 10.1016/s0049-0172(96)80044-8.
Vasculitis as a complication of lymphoproliferative diseases is relatively uncommon. Cutaneous vasculitis is most commonly necrotizing and leukocytoclastic. Granulomatous vasculitis occurs rarely with lymphoproliferative diseases, and even less commonly T-cell lymphocytic vasculitis with eosinophilia. The most common systemic vasculitis is caused by cryoglobulinemia, due to either lymphocytic lymphoma or Waldenström's macroglobulinemia. Other unusual associations involving systemic vasculitides include polyarteritis nodosa and hairy cell leukemia, Wegener's granulomatosis and Hodgkin's disease, granulomatous angiitis of the central nervous system and lymphoma, temporal arteritis and lymphoma, and Henoch-Schönlein purpura and lymphoma. The vasculitis may predate the diagnosis of the lymphoproliferative disease, and patients with vasculitis should be screened and monitored for lymphoproliferative diseases.
血管炎作为淋巴增殖性疾病的一种并发症相对少见。皮肤血管炎最常见的类型是坏死性和白细胞破碎性血管炎。肉芽肿性血管炎很少与淋巴增殖性疾病相关，而伴有嗜酸性粒细胞增多的T细胞淋巴细胞性血管炎则更为罕见。最常见的系统性血管炎由冷球蛋白血症引起，病因是淋巴细胞淋巴瘤或华氏巨球蛋白血症。其他涉及系统性血管炎的不寻常关联包括结节性多动脉炎与毛细胞白血病、韦格纳肉芽肿与霍奇金病、中枢神经系统肉芽肿性血管炎与淋巴瘤、颞动脉炎与淋巴瘤，以及过敏性紫癜与淋巴瘤。血管炎可能在淋巴增殖性疾病诊断之前出现，患有血管炎的患者应接受淋巴增殖性疾病的筛查和监测。
