1Department of Dermatovenereology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia; 2School of Dental Medicine, University of Zagreb, Zagreb, Croatia; 3Unit of Dermatology and Venereology, Zabok General Hospital, Bračak/Zabok, Croatia; 4Faculty of Dental Medicine and Health, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 5Ljudevit Jurak Department of Pathology, Sestre milosrdnice University Hospital Center, Zagreb, Croatia.
Acta Clin Croat. 2021 Dec;60(4):711-721. doi: 10.20471/acc.2021.60.04.19.
Although there are many single case reports on paraneoplastic dermatoses in the literature, there are very rare articles containing multiple cases. A retrospective study was performed to examine paraneoplastic dermatoses and accompanying malignancies based on skin manifestations and appropriate diagnostic evaluations. We recorded outcomes, current conditions, and surgical/oncologic treatments. Analysis revealed paraneoplastic dermatoses in 17 patients with various skin lesions, i.e. eczematous dermatitis, vasculitis, subacute cutaneous lupus erythematosus, pruritus, chronic urticaria/angioedema, alopecia areata, flushing, bullous pemphigoid, dermatomyositis, and localized scleroderma (morphea). They were associated with different solid and hematologic malignancies (3 gastric, 2 prostate, 2 bladder, 2 thyroid, and 2 lymphoma), along with 1 case each of the following: lung, hepatocellular, esophageal, endometrial, kidney, and multiple myeloma. The majority of skin lesions gradually regressed after malignancy treatment. To our knowledge, our three cases of paraneoplastic eczematous dermatitis are the first to be associated with gastric, prostate and endometrial cancer. Additionally, we report a case of a patient with alopecia areata of the beard associated with thyroid cancer. Early malignancy detection based on skin markers makes early introduction of surgical/oncologic therapy possible and usually leads to skin lesion regression while reducing revolving door visits to specialists and the (financial) burden on the healthcare system.
尽管文献中有许多关于副肿瘤性皮肤病的个案报告，但很少有包含多个病例的文章。本回顾性研究根据皮肤表现和适当的诊断评估，检查了副肿瘤性皮肤病和伴随的恶性肿瘤。我们记录了结果、当前状况以及手术/肿瘤治疗情况。分析显示，17 名患者存在多种皮肤病变，即湿疹性皮炎、血管炎、亚急性皮肤红斑狼疮、瘙痒、慢性荨麻疹/血管性水肿、斑秃、潮红、大疱性类天疱疮、皮肌炎和局限性硬皮病（硬斑病）。它们与不同的实体瘤和血液恶性肿瘤（3 例胃癌、2 例前列腺癌、2 例膀胱癌、2 例甲状腺癌和 2 例淋巴瘤）有关，此外还有 1 例肺癌、1 例肝细胞癌、1 例食管癌、1 例子宫内膜癌、1 例肾癌和 1 例多发性骨髓瘤。大多数皮肤病变在恶性肿瘤治疗后逐渐消退。据我们所知，我们报告的 3 例副肿瘤性湿疹性皮炎是首例与胃癌、前列腺癌和子宫内膜癌相关的病例。此外，我们还报告了 1 例甲状腺癌伴 beard 部斑秃的病例。基于皮肤标志物早期发现恶性肿瘤，可早期引入手术/肿瘤治疗，通常可导致皮肤病变消退，同时减少专科医生的轮诊次数和医疗系统的（经济）负担。
