Soda G, Bosco D, Baiocchini A, Melis M
Department of Experimental Medicine and Pathology, University La Sapienza of Rome.
Pathologica. 1996 Jun;88(3):192-5.
We present a case report of a young asiatic women presenting Kikuchi's lymphadenitis, a suprahyoidea mass, pharyngitis, fever, weakness and lack of appetite. The clinical picture quickly improved after biopsy until complete remission within two months. Sierologic studies showed significant antibody titres revealing a previous EBV infection; they were also negative for Toxotest, HbsAg, HIV and serogroup 3 and 9 Yersinia Enterocolitica. Histological findings showed necrotic changes and large foci of infiltration in the cortex and/or paracortex. They consisted of variable numbers of small lymphocytes, immunoblasts, macrophages and so-called plasmacytoid monocytes, neutrophils were absent. Immunohistochemistry revealed within the lesion T-Lymphocytes displaying a phenotype CD4+ while T-Lymphocytes CD8+ were observed in the paracortex and in the peripheral region of the lesion.
我们报告一例年轻亚洲女性病例，该患者表现为菊池淋巴结炎、舌骨上肿物、咽炎、发热、乏力及食欲不振。活检后临床症状迅速改善，直至两个月内完全缓解。血清学研究显示抗体滴度显著升高，提示既往有EB病毒感染；弓形虫检测、乙肝表面抗原、HIV及3型和9型小肠结肠炎耶尔森菌血清学检测均为阴性。组织学检查发现皮质和/或副皮质有坏死改变及大片浸润灶。浸润细胞包括数量不等的小淋巴细胞、免疫母细胞、巨噬细胞及所谓的浆细胞样单核细胞，未见中性粒细胞。免疫组化显示病变内T淋巴细胞呈CD4+表型，而CD8+ T淋巴细胞见于副皮质及病变周边区域。
