Abbott B J, Fukuda D S, Archer R A
Experientia. 1977 Jun 15;33(6):718-20. doi: 10.1007/BF01944147.
Microorganisms were screened for their ability to modify 2 synthetic cannabinoid substrates (I and II). Structure analyses revealed that microorganisms transformed the substrates by (a) primary oxidation of the side chain, beta-oxidation of the side chain, ketone formation on the side chain or cyclohexene ring, (b) secondary hydroxylation on the side chain, (c) aromatization of the cyclohexene ring, and (d) tertiary hydroxylation at the b/c ring juncture.
筛选微生物对两种合成大麻素底物（I和II）的修饰能力。结构分析表明，微生物通过以下方式转化底物：(a) 侧链的一级氧化、侧链的β-氧化、侧链或环己烯环上形成酮；(b) 侧链的二级羟基化；(c) 环己烯环的芳构化；以及(d) b/c环连接处的三级羟基化。
