Fesus L, Madi A, Balajthy Z, Nemes Z, Szondy Z
Department of Biochemistry, University Medical School of Debrecen, Hungary.
Experientia. 1996 Oct 31;52(10-11):942-9. doi: 10.1007/BF01920102.
Clarification of the molecular details of forms of natural cell death, including apoptosis, has become one of the most challenging issues of contemporary biomedical sciences. One of the effector elements of various cell death pathways is the covalent cross-linking of cellular proteins by transglutaminases. This review will discuss the accumulating data related to the induction and regulation of these enzymes, particularly of tissue type transglutaminase, in the molecular program of cell death. A wide range of signalling pathways can lead to the parallel induction of apoptosis and transglutaminase, providing a handle for better understanding the exact molecular interactions responsible for the mechanism of regulated cell death.
阐明包括凋亡在内的自然细胞死亡形式的分子细节，已成为当代生物医学科学最具挑战性的问题之一。各种细胞死亡途径的效应元件之一是转谷氨酰胺酶对细胞蛋白质的共价交联。本综述将讨论与这些酶，特别是组织型转谷氨酰胺酶在细胞死亡分子程序中的诱导和调节相关的积累数据。广泛的信号通路可导致凋亡和转谷氨酰胺酶的平行诱导，为更好地理解调节细胞死亡机制的确切分子相互作用提供了一个切入点。
