Lennartz R C, Hellems K L, Mook E R, Gold P E
Department of Psychology, University of Virginia, Charlottesville 22903, USA.
Behav Neurosci. 1996 Oct;110(5):1033-9. doi: 10.1037//0735-7044.110.5.1033.
Both systemic and central injections of glucose can enhance memory. For example, glucose reverses impairments on inhibitory avoidance resulting from intra-amygdala injections of morphine. The present experiment investigated the ability of glucose to reverse memory impairments resulting from intra-amygdala injections of propranolol, a beta-noradrenergic antagonist. Pretraining administration of 10 microg propranolol significantly reduced inhibitory avoidance retention latencies but had no effect on performance in a spontaneous alternation task. Coadministration of glucose into the amygdala at 3 doses (1.5, 3.0, and 6.0 microg) did not reverse the propranolol-induced inhibitory avoidance deficits. However, coadministration of 2.5 microg of glutamate with the propranolol did reverse these deficits. The ability of glucose to reverse impairments following intra-amygdala injections of morphine but not propranolol may reflect the neurotransmitter system or systems through which glucose exerts its effects.
全身性和中枢性注射葡萄糖均可增强记忆力。例如，葡萄糖可逆转杏仁核内注射吗啡所导致的抑制性回避损伤。本实验研究了葡萄糖逆转杏仁核内注射β-去甲肾上腺素能拮抗剂普萘洛尔所导致的记忆损伤的能力。训练前给予10微克普萘洛尔显著缩短了抑制性回避保持潜伏期，但对自发交替任务的表现没有影响。将3种剂量（1.5、3.0和6.0微克）的葡萄糖与普萘洛尔共同注射到杏仁核中，并未逆转普萘洛尔诱导的抑制性回避缺陷。然而，将2.5微克谷氨酸与普萘洛尔共同注射则确实逆转了这些缺陷。葡萄糖能够逆转杏仁核内注射吗啡后的损伤，但不能逆转注射普萘洛尔后的损伤，这可能反映了葡萄糖发挥作用所通过的一个或多个神经递质系统。
